2. Apoptosis
  3. MDM-2/p53
  4. RDR03871

RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively.

For research use only. We do not sell to patients.

RDR03871 Chemical Structure

RDR03871 Chemical Structure

CAS No. : 286008-51-3

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Based on 1 publication(s) in Google Scholar

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Description

RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].

Cellular Effect
Cell Line Type Value Description References
BTI-TN-5B1-4 IC50
> 100 μM
Compound: 35
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroanilide as substrate after 20 mins by spectrophotometric analysis in presence of Bacillus coagulans GST-tagge
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroanilide as substrate after 20 mins by spectrophotometric analysis in presence of Bacillus coagulans GST-tagge
[PMID: 23507151]
Molecular Weight

408.81

Formula

C18H16ClF3N6
CAS No.
SMILES

FC(F)(F)C1=CC=CC(NCCNC2=NC(C3=NC=CC=C3)=NC(C)=C2Cl)=N1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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RDR03871 Related Classifications

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Keywords:

RDR03871286008-51-3RDR 03871RDR-03871MDM-2/p53MDM2-p53MDM4-p53Inhibitorinhibitorinhibit

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