2. Neuronal Signaling
  3. Amyloid-β
  4. Cl-NQTrp

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.

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Cl-NQTrp Chemical Structure

Cl-NQTrp Chemical Structure

CAS No. : 185351-23-9

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Based on 1 publication(s) in Google Scholar

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Description

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2].

In Vitro

Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils[1].
Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau[2].
Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elavc155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control[2].
Dosage: 0.75 mg/mL.
Administration: Dripped every other day.
Result: Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).
Molecular Weight

394.81

Formula

C21H15ClN2O4
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

ClC(C(C1=C(C=CC=C1)C2=O)=O)=C2N[C@H](C(O)=O)CC3=CNC4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (253.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5329 mL 12.6643 mL 25.3286 mL
5 mM 0.5066 mL 2.5329 mL 5.0657 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
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% 
+
%
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%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5329 mL 12.6643 mL 25.3286 mL 63.3216 mL
5 mM 0.5066 mL 2.5329 mL 5.0657 mL 12.6643 mL
10 mM 0.2533 mL 1.2664 mL 2.5329 mL 6.3322 mL
15 mM 0.1689 mL 0.8443 mL 1.6886 mL 4.2214 mL
20 mM 0.1266 mL 0.6332 mL 1.2664 mL 3.1661 mL
25 mM 0.1013 mL 0.5066 mL 1.0131 mL 2.5329 mL
30 mM 0.0844 mL 0.4221 mL 0.8443 mL 2.1107 mL
40 mM 0.0633 mL 0.3166 mL 0.6332 mL 1.5830 mL
50 mM 0.0507 mL 0.2533 mL 0.5066 mL 1.2664 mL
60 mM 0.0422 mL 0.2111 mL 0.4221 mL 1.0554 mL
80 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7915 mL
100 mM 0.0253 mL 0.1266 mL 0.2533 mL 0.6332 mL
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Cl-NQTrp Related Classifications

Keywords:

Cl-NQTrp185351-23-9Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’sdiseaseTauPHF6ProteinmisfoldingaggregationInhibitorinhibitorinhibit

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