ACPL2 Protein, Human (HEK293, His)

The ACPL2 protein plays a critical role in the regulation of glycosaminoglycan (GAG) chains by catalyzing the 2-O-dephosphorylation of xylose in proteoglycans. This step is critical for the synthesis of sulfated GAGs, including heparan sulfate and chondroitin sulfate. ACPL2 Protein, Human (HEK293, His) is the recombinant human-derived ACPL2 protein, expressed by HEK293 , with C-His labeled tag.

The ACPL2 protein assumes a crucial role in the regulation of mature glycosaminoglycan (GAG) chains by catalyzing the 2-O-dephosphorylation of xylose within the glycosaminoglycan-protein linkage region of proteoglycans. This process holds significance in the synthesis of sulfated GAGs, such as heparan sulfate and chondroitin sulfate, on the common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins. The stepwise addition of monosaccharide residues by specific glycosyltransferases leads to the formation of this linkage region, with xylose 2-O-dephosphorylation serving as a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. ACPL2's enzymatic activity in this context underscores its pivotal role in the fine-tuned control of GAG chain assembly, contributing to the precise regulation of glycosaminoglycan structures.

Human

HEK293

C-His

Q8TE99-1/NP_689495.1 (M1-F480)

92370  [NCBI]

Approximately 50 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.