AIM2 - absent in melanoma 2 Gene

Homo sapiens

Also known as PYHIN4

Gene ID: 9447 | Gene type: protein coding

About AIM2

Cytogenetic location: 1q23.1-q23.2 Genomic coordinates (GRCh38): 1:159,055,051-159,147,132 (from NCBI)

This gene has 8 transcripts (splice variants), 48 orthologues and 3 paralogues. Biased expression in lymph node (RPKM 9.4), appendix (RPKM 5.0) and 5 other tissues.

Summary

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

AIM2 Products(2)

mRNA	Protein	Name
NM_001348247.2	NP_001335176.1	interferon-inducible protein AIM2 isoform 2
NM_004833.3	NP_004824.1	interferon-inducible protein AIM2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activator activity	IDA IDA: Inferred from direct assay	19158679	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	19158675	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19158676	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	26197926	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19158675	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	23530044	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	19158676	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	19158675	GOA
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	19158679	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16432157	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19158675	GOA
involved in positive regulation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	19158676	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	19158675	GOA
involved in pyroptosome complex assembly	IDA IDA: Inferred from direct assay	19158676	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	19158675	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	16432157	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of AIM2 inflammasome complex	IDA IDA: Inferred from direct assay	19158676	GOA
part of AIM2 inflammasome complex	IPI IPI: Inferred from physical interaction	24630722	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	8454910	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19158676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIM2 Protein Structure

PYRIN

HIN

0
100
200
300
343 a.a.

Protein Preferred Names

Protein Names

interferon-inducible protein AIM2

AIM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	22286270
Intra	AIM2	O14862	AIM2	Homo sapiens	O14862	Crosslink	19158676
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	19158675
Intra	AIM2	O14862	NPM1	Homo sapiens	P06748	Crosslink	30021884
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	19158676
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	GMS	24630722
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	FPS	24630722
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	EM	24630722
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Tag CoIP	19158675
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Tag CoIP	24237704
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Pull Down	19158676
Intra	AIM2	O14862	AIM2	Homo sapiens	O14862	EM	24630722
Intra	AIM2	O14862	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	22286270

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AIM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72816	AIM2 Protein, Human (sf9, GST)	O14862/NP_004824.1 (M1-T343)	≥95%

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Brucellosis

Mediterranean Fever	Malta Fever
Undulant Fever	Gibraltar Fever
Bang'S Disease	Maltese Fever
Cyprus Fever	Rock Fever
Brucellosis Infection	Brucella Infection

Tularemia

Francisella Tularensis Infection	Deerfly Fever
Lemming Fever	Ohara Disease
Pahvant Valley Plague	Rabbit Fever
Yatobyo

Renal Infectious Disease

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Muckle-Wells Syndrome

MWS	Urticaria-Deafness-Amyloidosis Syndrome
Uda Syndrome	Neutrophilic Urticaria
Urticaria, Deafness And Amyloidosis	Cryopyrin-Associated Periodic Syndrome 2
Caps2	Muckle Wells Syndrome
Urticaria-Deafness-Amyloidosis	Cryopyrin-Associated Periodic Syndromes

Pneumonic Tularemia

Pulmonary Tularemia	Bronchopneumonic Tularemia
Pneumonic Tularaemia

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria	Fcas
Familial Polymorphous Cold Eruption	Fcu
Cold Hypersensitivity

Colon Sarcoma

Colonic Sarcoma

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Salmonellosis

Salmonella Infections

Salmonella Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0822	Shikonin	Inhibitor	99.80%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.23%	Unkown
HY-150751	ODN TTAGGG	Antagonist	99.87%	Unkown
HY-152670	JC2-11	Inhibitor	98.02%	Unkown
HY-144223	NLRP3/AIM2-IN-2	Inhibitor	99.88%	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	99.87%	Unkown
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-130480	Fructose-arginine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AIM2	RGD	RGD:1307283
Mus musculus	AIM2	MGD	MGI:2686159

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