Cathepsin E Protein, Rat (HEK293, His)

Cathepsin E Protein is an aspartate protease that plays an important role in protein degradation, bioactive protein production and antigen processing.The Cathepsin E Protein is involved in the execution of age-induced neuronal death pathways, as well as overstimulation of glutamate receptors by excitotoxins and transient forebrain ischemia.Cathepsin E Protein is a potential early biomarker of pancreatic ductal adenocarcinoma (PDAC).Cathepsin E Protein, Rat (HEK293, His) is the recombinant rat-derived Cathepsin E protein, expressed by HEK293 , with C-His labeled tag.

Cathepsin E is an aspartic protease and member of the peptidase A1 protease family, expressed primarily in the immune system, gastrointestinal system, lymphoid tissue, red blood cells and cancer cells. Cathepsin E decomposes proteins by hydrolyzing peptide bonds at specific peptide sequence sites and plays an important role in protein degradation, bioactive protein production and antigen processing. Cathepsin E is involved in the execution of age-induced neuronal death pathways, as well as overstimulation of glutamate receptors by excitotoxins and transient forebrain ischemia. Cathepsin E may play a role in intestinal metaplasia and differentiation into highly differentiated adenocarcinomas and in dendritic cells^[1][2][3][4].

Rat

HEK293

C-His

AAH62002 (M1-P398)

25424  [NCBI]

Approximately 42.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.