CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His)

CD26/dipeptidyl peptidase 4 is a key cell surface receptor for T cell activation. It binds to ADA, CAV1, IGF2R and PTPRC to promote T cell proliferation and NF-kappa-B activation. CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) is 732 a.a., with molecular weight of ~85.9 kDa.

The CD26/Dipeptidyl Peptidase 4 protein serves as a cell surface glycoprotein receptor crucial for the costimulatory signal essential in T-cell receptor (TCR)-mediated T-cell activation. Functioning as a positive regulator of T-cell coactivation, CD26 binds to ADA, CAV1, IGF2R, and PTPRC. Its interactions with CAV1 and CARD11 induce T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Additionally, CD26's association with ADA regulates lymphocyte-epithelial cell adhesion, while its partnership with FAP contributes to pericellular proteolysis of the extracellular matrix (ECM), facilitating the migration and invasion of endothelial cells into the ECM. CD26 may also play a role in promoting lymphatic endothelial cell adhesion, migration, and tube formation. When overexpressed, CD26 enhances cell proliferation, a process inhibited by GPC3. Beyond its coactivation role, CD26 functions as a serine exopeptidase with dipeptidyl peptidase activity, regulating various physiological processes by cleaving peptides in the circulation, including chemokines, mitogenic growth factors, neuropeptides, and peptide hormones, specifically targeting peptides with unsubstituted N-termini when the penultimate residue is proline.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

C-His

P28843 (S29-H760)

13482  [NCBI]

Approximately 85.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.