2. Gene
  3. Dpp4 - dipeptidylpeptidase 4 Gene

Dpp4 - dipeptidylpeptidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cd26; THAM; Dpp-4

Gene ID: 13482 | Gene type: protein coding

About Dpp4

Chromosome 2: 62,160,417-62,242,575 reverse strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 286 orthologues, 6 paralogues and is associated with 31 phenotypes. Biased expression in large intestine adult (RPKM 3.2), small intestine adult (RPKM 11.7) and 11 other tissues.

Summary

Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (Dipeptidyl Peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Dpp4 Products(2)

mRNA Protein Name
NM_001159543.1 NP_001153015.1 dipeptidyl peptidase 4 isoform 2
NM_010074.3 NP_034204.1 dipeptidyl peptidase 4 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
16712972 MGI
acts upstream of or within locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
16712972 MGI
acts upstream of or within psychomotor behavior IMP
IMP: Inferred from mutant phenotype
16712972 MGI
Cellular Component GO Annotation Evidence Reference Source
located in intercellular canaliculus IDA
IDA: Inferred from direct assay
12068294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dpp4 Protein Structure

DPPIV_rep

DPPIV_rep: pfam18811 (35 - 55)

DPPIV_N

DPPIV_N: pfam00930 (101 - 471)

Peptidase_S9

Peptidase_S9: pfam00326 (552 - 756)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 4

DPP IV

T-cell activation antigen CD26

dipeptidyl peptidase IV

thymocyte-activating molecule

Recombinant Dpp4 Proteins

Cat. No. Product Name Accession Purity
HY-P75428 CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) P28843 (S29-H760) ≥95%
HY-P75429 CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, Fc) P28843 (S29-H760) ≥95%

Related Agents

Approval
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13749 Sitagliptin Inhibitor 99.75% Yes
HY-10284 Linagliptin 99.91% Unkown
HY-13749A Sitagliptin phosphate Inhibitor 99.85% Yes
HY-10285 Saxagliptin Inhibitor 99.96% Yes
HY-15981 Omarigliptin Inhibitor 99.88% Unkown
HY-13749B Sitagliptin phosphate monohydrate Inhibitor 99.49% Yes
HY-14806 Teneligliptin Inhibitor 99.85% Unkown
HY-A0023 Alogliptin Benzoate Inhibitor 99.99% Unkown
HY-A0023A Alogliptin Inhibitor 99.92% Unkown
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.87% Unkown
HY-15408 Trelagliptin Inhibitor 99.54% Unkown
HY-14877 Anagliptin Inhibitor 99.91% Unkown
HY-15408A Trelagliptin succinate Inhibitor 99.96% Unkown
HY-14806A Teneligliptin hydrobromide Inhibitor 99.99% Unkown
HY-16448 Saxagliptin hydrochloride Inhibitor 99.71% Yes
HY-14892 Gemigliptin Inhibitor / Unkown
HY-108795A Albiglutide fragment TFA Agonist 99.12% Unkown
HY-10285A Saxagliptin hydrate Inhibitor ≥99.0% Yes
HY-14877A Anagliptin hydrochloride Inhibitor / Unkown
HY-108795 Albiglutide fragment Agonist / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9805 Anti-MERS-3A1 mAb Inhibitor / Unkown
HY-P9806 Anti-MERS-D12 mAb Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-117985B Evogliptin tartrate 99.71% Phase 4
HY-14806S Teneligliptin-d8 Inhibitor / Phase 4
HY-117985 Evogliptin / Phase 4
HY-10286 Dutogliptin Inhibitor 99.32% Phase 3
HY-112668 Retagliptin phosphate Inhibitor 99.89% Phase 3
HY-147257 Cofrogliptin Inhibitor 99.07% Phase 3
HY-10286A Dutogliptin tartrate Inhibitor / Phase 3
HY-12528 DBPR108 Inhibitor 98.75% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99466 Begelomab Inhibitor ≥95.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (54)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% Unkown
HY-14892A Gemigliptin tartrate Inhibitor 98.17% Unkown
HY-P2543 Neuropeptide Y (3-36) (human, rat) Agonist 95.78% Unkown
HY-112668A Retagliptin Inhibitor 98.51% Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.00% Unkown
HY-147401 Sitagliptin fenilalanil Inhibitor 99.76% Unkown
HY-13749AS Sitagliptin-d4 phosphate Inhibitor 99.48% Unkown
HY-123377A Fotagliptin benzoate Inhibitor 99.19% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-10284S Linagliptin-d4 99.62% Unkown
HY-124958 NDMC101 Inhibitor 99.91% Unkown
HY-13749S1 Sitagliptin-d4 hydrochloride / Unkown
HY-A0023AS Alogliptin-13C,d3 Inhibitor / Unkown
HY-RS03963 DPP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-112668B Retagliptin hydrochloride / Unkown
HY-117985A Evogliptin hydrochloride Inhibitor / Unkown
HY-123377 Fotagliptin Inhibitor / Unkown
HY-147401A Sitagliptin fenilalanil hydrochloride Inhibitor 98.94% Unkown
HY-10284S1 Linagliptin-13C,d3 / Unkown
HY-10284S3 Linagliptin-d3-1 / Unkown
HY-120828 Albenatide Agonist / Unkown
HY-121029 Bisegliptin / Unkown
HY-125330 Denagliptin tosylate / Unkown
HY-13749C (S)-Sitagliptin phosphate Inhibitor / Unkown
HY-146455 DPP-4-IN-3 Inhibitor / Unkown
HY-146468 DPP-4/GPR119 modulator 1 / Unkown
HY-146469 DPP-4/GPR119 modulator 2 / Unkown
HY-14806S1 Teneligliptin-d4 Inhibitor / Unkown
HY-151383 DPP-4-IN-1 Inhibitor / Unkown
HY-151384 DPP-4-IN-2 Inhibitor / Unkown
HY-15408S Trelagliptin-13C,d3 Inhibitor / Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-155961 Antidiabetic agent 2 Inhibitor / Unkown
HY-157390 DPP-4-IN-9 Inhibitor / Unkown
HY-158315 NZ-97 Inhibitor / Unkown
HY-159491 DPP-4-IN-11 Inhibitor / Unkown
HY-161428 ZINC000003015356 Inhibitor / Unkown
HY-162513 DPP-4-IN-10 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-168621 DPP-4-IN-13 Inhibitor / Unkown
HY-169110 DPP-4-IN-12 Inhibitor / Unkown
HY-N9725 16-Hydroxycleroda-3,13-dien-15,16-olide Inhibitor / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS03964 Dpp4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03965 Dpp4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-103432 DPP4-In / Unkown
HY-109060 Garvagliptin Inhibitor / Unkown
HY-110051 DPP4-In hydrochloride / Unkown
HY-119266 HTS13517 Inhibitor / Unkown
HY-13749D (Rac)-Sitagliptin Inhibitor / Unkown
HY-139792 Besigliptin tosylate / Unkown
HY-16656 BMS-767778 Inhibitor / Unkown
HY-167680 Denagliptin / Unkown
HY-N8134 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpp4 NCBI NCBI:1803
Macaca fascicularis Dpp4 NCBI NCBI:102133935