Cochlin/COCH Protein, Human (HEK293, His)

Cochlin/COCH protein is involved in regulating cell shape and motility in the trabecular meshwork. It exists as a monomer and may form homodimers. Additionally, Cochlin interacts with type II collagen, SLC44A2, and ANXA2. Cochlin/COCH Protein, Human (HEK293, His) is the recombinant human-derived Cochlin/COCH protein, expressed by HEK293 , with N-His labeled tag.

Cochlin (COCH) protein emerges as a key player in orchestrating cell shape and motility within the trabecular meshwork. Existing as a monomer, Cochlin also exhibits the potential to form homodimers. Its interaction with type II collagen highlights its involvement in the extracellular matrix dynamics. Additionally, Cochlin engages in critical interactions with SLC44A2, emphasizing its role in cellular processes. Furthermore, its association with ANXA2 underscores its participation in intricate molecular networks essential for cellular functions.

Human

HEK293

N-10*His

O43405 (E25-Q550)

1690  [NCBI]

EGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ

Approximately 66&48&18 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.