2. Recombinant Proteins
  3. Viral Proteins
  4. HIV Proteins
  5. HIV-1 gp160
  6. envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His)

envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His)

Cat. No.: HY-P76383
Handling Instructions

Envelope glycoprotein gp160 Protein (HIV-1 gp160 Protein) is the sole antigenic protein on the surface of the HIV-1 virion and mediates HIV-1 entry into target cells. The endoproteolytic processing of HIV-1 gp160 membrane glycoprotein precursor into gp120 and gp41 is necessary for formation of infectious HIV particles. HIV-1 gp160 induces endothelial cell apoptosis, which is mediated by CXCR4 chemokine receptor. envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag.

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Description

Envelope glycoprotein gp160 Protein (HIV-1 gp160 Protein) is the sole antigenic protein on the surface of the HIV-1 virion and mediates HIV-1 entry into target cells. The endoproteolytic processing of HIV-1 gp160 membrane glycoprotein precursor into gp120 and gp41 is necessary for formation of infectious HIV particles. HIV-1 gp160 induces endothelial cell apoptosis, which is mediated by CXCR4 chemokine receptor[1][2][3][4]. envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag.
Background

HIV-1 envelope glycoprotein is synthesized as a precursor glycoprotein, gp160, and is then processed into gp120 and gp41[2]. Envelope glycoprotein gp160 Protein (HIV-1 gp160 Protein) is the sole antigenic protein on the surface of the HIV-1 virion and mediates HIV-1 entry into target cells[1]. Noticeably, endoproteolytic processing of HIV-1 gp160 membrane glycoprotein precursor into gp120 and gp41 is necessary for formation of infectious HIV particles[3]. HIV-1 gp160 induces endothelial cell apoptosis and activates caspase-3, which is mediated by CXCR4 chemokine receptor[4].
Species

Virus
Source

HEK293
Tag

C-His
Accession

ADD25380 (W32-R504)
Gene ID

/
Molecular Construction
N-term
HIV-1 gp160 (W32-R504)
Accession # ADD25380
His
C-term
Synonyms
HIV-1 gp160 Protein (gp120 subunit) (group N, strain 06CM-U14296)
Molecular Weight

Approximately 54.4 kDa.
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His)
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