1. Recombinant Proteins
  2. CD Antigens Fc Receptors Biotinylated Proteins
  3. Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  4. Fc gamma RII/CD32 FCGR2A/CD32a
  5. FCGR2A/CD32a
  6. Fc gamma RIIA/CD32a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)

Fc gamma RIIA/CD32a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P75642
Data Sheet Handling Instructions Technical Support

Fc gamma RIIA/CD32a protein belongs to the FC family of receptor proteins and is a type 1 transmembrane glycoprotein that binds immunoglobulin subtypes IgG1-4 and can bind c-reactive protein (CRP) with high affinity. It plays an important role in immune regulation in many infections, including malaria. Fc gamma RIIA/CD32a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Fc gamma RIIA/CD32a protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

For research use only. We do not sell to patients.

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  • Biological Activity

  • Technical Parameters

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Description

Fc gamma RIIA/CD32a protein belongs to the FC family of receptor proteins and is a type 1 transmembrane glycoprotein that binds immunoglobulin subtypes IgG1-4 and can bind c-reactive protein (CRP) with high affinity. It plays an important role in immune regulation in many infections, including malaria. Fc gamma RIIA/CD32a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Fc gamma RIIA/CD32a protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Background

Fc gamma RIIA/CD32a Protein contains a polymorphic variant (H/R131) that is associated with susceptibility variability in bacterial diseases and Plasmodium falciparum parasitemia. Fc gamma RIIA/CD32a Protein is a low-affinity IgG receptor that binds immunoglobulin subtypes IgG1-4 and can bind c-reactive protein (CRP) with high affinity, playing an important role in immune regulation[1].
Fc gamma RIIA/CD32a Protein inhibits the production of type I and type III Interferons in human marrow immune cells[2].
Fc gamma RIIA/CD32a protein promotes phagocytosis of opsonized antigens, further promoting immune defense mechanisms[3].

Species

Cynomolgus

Source

HEK293

Tag

C-Avi;C-His

Accession

Q8SPW4 (A30-G204)

Gene ID
Molecular Construction
N-term
CD32a (A30-G204)
Accession # Q8SPW4
Avi-6*His
C-term
Synonyms
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-a; CD32; FCGR2A; FCG2; IGFR2
Molecular Weight

33-35 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Fc gamma RIIA/CD32a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) Related Classifications

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Fc gamma RIIA/CD32a Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)
Cat. No.:
HY-P75642
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