FGFRL1 Protein, Human (HEK293, His)

The FGFRL1 protein negatively affects cell proliferation, revealing its role as a potential regulator during cell growth. In addition, it interacts with FGF2, showing significant but low affinity for this fibroblast growth factor. FGFRL1 Protein, Human (HEK293, His) is the recombinant human-derived FGFRL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFRL1 Protein, Human (HEK293, His) is 354 a.a., with molecular weight of ~65 kDa.

FGFRL1 (Fibroblast Growth Factor Receptor-Like 1) is a protein known for its negative regulatory effect on cell proliferation. Unlike typical fibroblast growth factor receptors, FGFRL1 exhibits low-affinity interactions with FGF2, a member of the fibroblast growth factor family. This distinct binding characteristic suggests a unique role for FGFRL1 in modulating cellular responses to FGF signaling, potentially influencing cell growth and differentiation. The negative impact on cell proliferation implicates FGFRL1 as a regulatory component in cellular processes, and its interaction with FGF2 highlights its potential involvement in fine-tuning FGF-mediated signaling pathways. Ongoing research may further elucidate the specific mechanisms and downstream effects of FGFRL1 in cellular regulation.

Human

HEK293

C-6*His

Q8N441 (A25-P378)

53834  [NCBI]

ARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWP

Approximately 65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.