IL-12 beta Protein, Cynomolgus (HEK293, His)

IL-12 beta Protein, partnering with IL23A, produces the cytokine IL-23 vital in innate and adaptive immunity. Alongside IL-17, IL-23 orchestrates an immediate infection response in peripheral tissues. Binding to IL12RB1 and IL23R, IL-23 activates Jak-Stat signaling, preferentially stimulating memory T-cells, and induces pro-inflammatory cytokine production. Implicated in autoimmune inflammation and tumorigenesis, IL-23 serves as a growth factor for activated T and NK cells, enhances NK cell lytic activity, and triggers IFN-gamma production by resting PBMC. IL-12 beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-12 beta protein, expressed by HEK293, with C-His labeled tag. The total length of IL-12 beta Protein, Cynomolgus (HEK293, His) is 306 a.a., with molecular weight of 40-50 kDa.

The IL-12 beta Protein partners with IL23A, forming the IL-23 interleukin, a heterodimeric cytokine with essential functions in both innate and adaptive immunity. In conjunction with IL-17, IL-23 may orchestrate an immediate response to infection in peripheral tissues. Through binding to a heterodimeric receptor complex comprising IL12RB1 and IL23R, IL-23 initiates the Jak-Stat signaling cascade, preferentially stimulating memory T-cells over naive T-cells, and fostering the production of pro-inflammatory cytokines. Implicated in the induction of autoimmune inflammation, IL-23 may play a crucial role in autoimmune inflammatory diseases and tumorigenesis. Additionally, this cytokine acts as a growth factor for activated T and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and triggers the production of IFN-gamma by resting PBMC.

Cynomolgus

HEK293

C-His

A0A2K5TM36 (I23-S328)

102124858

40-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.