IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, Fc)

IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an essential component of the IL-1 receptor and plays an essential role in the inflammatory process^[1][2]. IL-1RAcP/IL-1 R3 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus IL-1RAcP protein with an hFc tag at the C-terminus and is expressed in HEK293 cells.

Interleukin-1 receptor accessory protein (IL-1RAcP), also known as IL-1 R3, belongs to the immunoglobulin (Ig) superfamily. IL-1RAcP can be detected in liver, skin, placenta, thymus and lung.
The cynomolgus IL-1RAcP protein shares 99.30% a.a sequence identity with human, 88.60% identity with rat and 88.42% identity with mouse.
IL-1RAcP contains three Ig-like domains and a cytoplasmic domain named Toll/IL-1 receptor (TIR) (position: 403-546 a.a), which has been implicated in signal transduction. IL-1RAcP also contains a single transmembrane region. IL-1RAcP is a co-receptor for IL1RL2, IL1R1 and IL1RL1 in the IL-36, IL-1 and IL-33 signaling system, respectively. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, links events at the plasma membrane level to downstream signaling pathways, mediates interleukin-1-dependent transcription factor activation and gene expression.
IL-1RAcP plays an essential role in the inflammatory process and can be used for the research of obesity, diabetics, endometriosis, atherosclerosis, and so on^[1][2][3].

Cynomolgus

HEK293

C-hFc

P59822-1/NP_001028132.1 (S21-E359)

574387  [NCBI]

Approximately 65.84 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Neveu PJ, et al. Mechanisms of behavioral and neuroendocrine effects of interleukin-1 in mice. Ann N Y Acad Sci. 2000;917:175-85.  [Content Brief]

  [2]. Zarezadeh Mehrabadi A, et al. The roles of interleukin-1 receptor accessory protein in certain inflammatory conditions. Immunology. 2022 May;166(1):38-46.  [Content Brief]

  [3]. Wesche H, et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem. 1997 Mar 21;272(12):7727-31.  [Content Brief]