2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins
  4. Interleukin & Receptors Cytokine Receptors
  5. IL-23 Receptor
  6. IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc)

IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc)

Cat. No.: HY-P75857
Handling Instructions

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 353 a.a., with molecular weight of ~64.9 kDa.

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Description

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 353 a.a., with molecular weight of ~64.9 kDa.
Background

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Interleukin 23 receptor contributes to interleukin-12 receptor binding and contributes to interleukin-23 receptor activity. Interleukin 23 receptor is involved_in defense response to Gram-negative bacterium and positive regulation of T cell proliferation[1][2][3][4][5].
Species

Rhesus Macaque
Source

HEK293
Tag

C-hFc
Accession

F6XR82 (M1-D353)
Gene ID

/
Molecular Construction
N-term
IL-23R (M1-D353)
Accession # F6XR82
hFc
C-term
Synonyms
Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R
Molecular Weight

Approximately 64.9 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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