IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc)

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. IL-23R Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Interleukin 23 receptor contributes to interleukin-12 receptor binding and contributes to interleukin-23 receptor activity. Interleukin 23 receptor is involved_in defense response to Gram-negative bacterium and positive regulation of T cell proliferation^{[1][2][3][4][5]}.

Rhesus Macaque

HEK293

C-hFc

F6XR82 (M1-D353)

/

Approximately 64.9 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.