INHBE Protein, Human (HEK293, Fc)

The INHBE protein is an important molecular switch that coordinates the inhibin and activin systems to regulate pituitary follicle-stimulating hormone secretion. Its critical role extends to multiple physiological functions, including hormone secretion, cell development, insulin release, and bone growth. INHBE Protein, Human (HEK293, Fc) is the recombinant human-derived INHBE protein, expressed by HEK293 , with N-hFc labeled tag. The total length of INHBE Protein, Human (HEK293, Fc) is 114 a.a., with molecular weight of ~40.9 kDa.

INHBE protein assumes a pivotal role in the intricate orchestration of the inhibin and activin systems, serving as a molecular switch to either inhibit or activate the secretion of follitropin by the pituitary gland. Within the broader context, inhibins and activins, and by extension, INHBE, contribute to the regulation of a myriad of physiological functions spanning hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development, and bone growth. The dynamic interplay between inhibins and activins is underscored by their opposing functions, where inhibins, typified by heterodimeric structures like Inhibin A and Inhibin B, counteract the actions of activins. Structurally, INHBE exists in homodimeric or heterodimeric configurations through its association with alpha and beta subunits, intricately linked by one or more disulfide bonds. Notably, inhibins present as heterodimers comprising one alpha and one beta subunit, while activins, whether in homodimeric or heterodimeric form, exclusively consist of beta subunits, exemplifying the nuanced and versatile regulatory roles played by INHBE in shaping diverse physiological responses.

Human

HEK293

N-hFc

P58166 (T237-S350)

83729  [NCBI]

TPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS

Approximately 40.9 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 (Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.) or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.