LDLRAD3 Protein, Human (HEK293, hFc)

LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, hFc) is the recombinant human-derived LDLRAD3, expressed by HEK293 , with C-hFc labeled tag. ,

The LDLRAD3 protein appears to have a significant impact on amyloid precursor protein (APP) processing, potentially leading to decreased production of soluble APP-alpha (sAPP-alpha) and an increase in the generation of the amyloidogenic P3 peptide. Furthermore, it is suggested to play a regulatory role in the activity and degradation of ITCH and NEDD4 E3 ligases, as indicated by studies. In the context of microbial infection, LDLRAD3 acts as a receptor for the Venezuelan equine encephalitis virus. These findings underscore the multifunctional nature of LDLRAD3, implicating it in key cellular processes related to protein processing, immune response, and viral interactions.

Measured by its binding ability in a functional ELISA. Immobilized human ITCH at 2μg/mL (100μL/well) can bind Biotinylated Human LDLRAD3. The ED₅₀ for this effect is 1.503 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized human ITCH at 2μg/mL (100μL/well) can bind Biotinylated Human LDLRAD3. The ED₅₀ for this effect is 1.503 μg/mL.

Human

HEK293

C-hFc

Q86YD5-1 (Q18-T173)

143458

QLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSIT

Approximately 55 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.