p63/TP73L Protein, Human (sf9, His-GST)

The p63/TP73L protein is a sequence-specific DNA-binding transcriptional regulator that exhibits diverse activities through its isoforms. Isoform 2 activates RIPK4 transcription, and binding of this protein to TP73/p73 initiates p53/TP53-dependent apoptosis in response to genotoxic stress. p63/TP73L Protein, Human (sf9, His-GST) is the recombinant human-derived p63/TP73L protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of p63/TP73L Protein, Human (sf9, His-GST) is 680 a.a., with molecular weight of ~125 kDa.

p63/TP73L Protein functions as a sequence-specific DNA binding transcriptional regulator with diverse activities mediated by its isoforms, each containing distinct transactivation and auto-regulating transactivation inhibiting domains. Isoform 2 specifically activates RIPK4 transcription, while the protein's engagement with TP73/p73 is crucial for initiating p53/TP53-dependent apoptosis in response to genotoxic stress and activated oncogenes. Additionally, p63 contributes to Notch signaling, potentially inducing JAG1 and JAG2, and plays a role in epithelial morphogenesis. The balance between DeltaN-type and TA*-type isoforms likely governs the maintenance of epithelial stem cell compartments and influences the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Furthermore, the protein is indispensable for limb formation from the apical ectodermal ridge and exerts its regulatory role by activating the transcription of the p21 promoter.

Human

Sf9 insect cells

N-His;N-GST

Q9H3D4 (M1-E680)

8626  [NCBI]

Approximately 125 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.