PDGF-BB Protein, Canine (P.pastoris, His)

PDGF-BB controls multiple cellular processes, including development, proliferation, migration, survival, and chemotaxis. It is essential for normal cell proliferation and recruitment, wound healing, vascular development, and glomerular formation in various tissues. PDGF-BB Protein, Canine (P.pastoris, His) is the recombinant canine-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Canine (P.pastoris, His) is 109 a.a., with molecular weight of ~14.9 kDa.

PDGF-BB, a pivotal growth factor, assumes a central role in governing diverse cellular processes, including embryonic development, cell proliferation, migration, survival, and chemotaxis. As a potent mitogen for mesenchymal cells, PDGF-BB is indispensable for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in various tissues, encompassing the central nervous system, skin, lung, heart, and placenta. Essential for blood vessel development and the formation of kidney glomeruli, PDGF-BB emerges as a key player in wound healing. The dynamic signaling of PDGF-BB is finely tuned through the formation of antiparallel homodimers linked by disulfide bonds and antiparallel heterodimers with PDGFA. These dimers intricately interact with PDGFRA and PDGFRB homodimers, as well as heterodimers formed by PDGFRA and PDGFRB, illustrating the complexity of PDGF-BB's engagement in various cellular activities. Additionally, PDGF-BB engages in interactions with XLKD1, LRP1, and SORL1, further highlighting its versatile involvement in cellular regulation.

Canine

P. pastoris

N-His

Q6Q7I7 (S82-T190)

442986  [NCBI]

Approximately 14.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.