PLTP Protein, Human (HEK293, His)

PLTP proteins are centrally involved in lipid metabolism, mediating the transfer of phospholipids and free cholesterol between lipoproteins and HDL. This includes the exchange of various molecules such as diacylglycerol, sphingomyelin, and phosphatidylcholine. PLTP Protein, Human (HEK293, His) is the recombinant human-derived PLTP protein, expressed by HEK293 , with C-His labeled tag.

PLTP Protein assumes a central role in lipid metabolism by mediating the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low-density lipoproteins or LDL and very low-density lipoproteins or VLDL) into high-density lipoproteins (HDL), as well as facilitating the exchange of phospholipids among triglyceride-rich lipoproteins. This extensive lipid transfer encompasses various molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside, and phosphatidyl ethanolamine. PLTP further plays a crucial role in remodeling HDL, influencing its size and composition. Additionally, the protein is a key player in the uptake of cholesterol from peripheral cells and tissues, facilitating its transport to the liver for degradation and excretion. Notably, two distinct forms of PLTP exist in plasma: an active form capable of transferring phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form lacking this capability, contributing to the nuanced regulation of lipid homeostasis.

Human

HEK293

C-His

P55058-1 (E18-V493)

5360  [NCBI]

70-80 kDa

Greater than 80% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.