Rnls Protein, Mouse (His-SUMO)

The Rnls protein catalyzes the oxidation of the less abundant 1,2-dihydro-β-NAD(P) and 1,6-dihydro-β-NAD(P) to form β-NAD(P)(+). Mainly secreted by the kidneys, this enzyme circulates in the blood and plays a vital role in regulating heart function and systemic blood pressure. Rnls Protein, Mouse (His-SUMO) is the recombinant mouse-derived Rnls protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

Renalase (Rnls) is an enzyme that catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). This enzyme is primarily secreted by the kidney, circulating in the blood and playing a crucial role in modulating cardiac function and systemic blood pressure. Renalase has been identified as a key factor in lowering blood pressure in vivo, achieved by decreasing cardiac contractility and heart rate while preventing a compensatory increase in peripheral vascular tone. This suggests a causal link between renalase, increased plasma catecholamine levels, and heightened cardiovascular risk. Notably, high concentrations of catecholamines activate plasma renalase, promoting its secretion and synthesis. The multifaceted functions of renalase underscore its significance in cardiovascular regulation and its potential as a therapeutic target for managing blood pressure and cardiovascular health.

Mouse

E. coli

N-His;N-SUMO

A7RDN6-1 (A18-I342)

67795  [NCBI]

ALLRKEITAPLYLGLWDKGGDIGGRMITASSPHNPRCTADLGAQYITCSPHYVKEHQNFYEELLAHGILKPLTSPIEGMKGKEGDCNFVAPQGFSSVIKYYLKKSGAEVSLKHCVTQIHLKDNKWEVSTDTGSAEQFDLVILTMPAPQILELQGDIVNLISERQREQLKSVSYSSRYALGLFYEVGMKIGVPWSCRYLSSHPCICFISIDNKKRNIESSECGPSVVIQTTVPFGVQHLEASEADVQKLMIQQLETILPGLPQPVATICHKWTYSQVTSSVSDRPGQMTLHLKPFLVCGGDGFTHSNFNGCISSALSVMKVLKRYI

Approximately 52.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.