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  3. SR-BI/SCARB1 Protein, Human (HEK293, His)

SR-BI/SCARB1 Protein, Human (HEK293, His)

Cat. No.: HY-P76657
COA Handling Instructions

The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells. As an HDL receptor, it crucially mediates selective cholesterol ether uptake and HDL-dependent cholesterol efflux. SR-BI/SCARB1 Protein, Human (HEK293, His) is the recombinant human-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of SR-BI/SCARB1 Protein, Human (HEK293, His) is 411 a.a., with molecular weight of 75-85 kDa.

For research use only. We do not sell to patients.

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Description

The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells. As an HDL receptor, it crucially mediates selective cholesterol ether uptake and HDL-dependent cholesterol efflux. SR-BI/SCARB1 Protein, Human (HEK293, His) is the recombinant human-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of SR-BI/SCARB1 Protein, Human (HEK293, His) is 411 a.a., with molecular weight of 75-85 kDa.

Background

SR-BI/SCARB1 Protein, functioning as a versatile receptor, binds to various ligands, including phospholipids, cholesterol ester, lipoproteins, phosphatidylserine, and apoptotic cells. As a receptor for HDL, it plays a crucial role in the selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Additionally, SR-BI facilitates the exchange of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins, albeit less efficiently than with HDL. Its involvement in phagocytosis of apoptotic cells, mediated by its phosphatidylserine binding activity, adds another layer to its functional repertoire. In the context of microbial infection, SR-BI acts as a receptor for the hepatitis C virus in hepatocytes, facilitating its cellular entry independently of the viral isolate genotype. The diverse ligand interactions and roles in cholesterol homeostasis, apoptotic cell clearance, and viral infection highlight SR-BI/SCARB1 as a multifunctional player in cellular processes.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q8WTV0-1/NP_001076428.1 (P33-Y443)

Gene ID

949  [NCBI]

Molecular Construction
N-term
SR-BI (P33-Y443)
Accession # Q8WTV0
His
C-term
Synonyms
Scavenger receptor class B member 1; SRB1; CLA-1; CD36; CD36L1
Molecular Weight

70-90 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

SR-BI/SCARB1 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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SR-BI/SCARB1 Protein, Human (HEK293, His)
Cat. No.:
HY-P76657
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