SR-BI/SCARB1 Protein, Mouse (HEK293, His-Fc)

The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells.Both isoform 1 and isoform 2 act as high-density lipoprotein (HDL) receptors, promoting cholesterol ether uptake and HDL-dependent cholesterol efflux.SR-BI/SCARB1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

SR-BI/SCARB1 functions as a versatile receptor with binding capabilities for various ligands, including phospholipids, cholesterol ester, lipoproteins, phosphatidylserine, and apoptotic cells. Both isoform 1 and isoform 2 serve as receptors for high-density lipoprotein (HDL), mediating the selective uptake of cholesteryl ether and facilitating HDL-dependent cholesterol efflux. Additionally, SR-BI/SCARB1 plays a role in the transport of free and esterified cholesterol between the cell surface and apolipoprotein B (apoB)-containing lipoproteins, as well as modified lipoproteins, albeit less efficiently than HDL. The receptor may also participate in the phagocytosis of apoptotic cells through its phosphatidylserine binding activity. Notably, the C-terminal region of SR-BI/SCARB1 interacts with PDZK1, highlighting its potential involvement in complex cellular processes and signaling pathways.

Mouse

HEK293

C-hFc;C-His

Q61009 (P33-V440)

20778  [NCBI]

PSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQV

115-120 kDa

Greater than 95% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.