2. Cell Cycle/DNA Damage Others
  3. DNA/RNA Synthesis Others
  4. RECQL5-IN-1

RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

RECQL5-IN-1 Chemical Structure

RECQL5-IN-1 Chemical Structure

CAS No. : 2718170-45-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 440 In-stock
Solution
10 mM * 1 mL in DMSO USD 440 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 640 In-stock
25 mg USD 1280 In-stock
50 mg USD 2060 In-stock
100 mg USD 3300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

RECQL5-IN-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
19.6 μM
Compound: 4a
Cytotoxicity against RECQL5 knock out human MCF7 cells assessed as inhibition of colony formation measured after 8 to 10 days by clonogenic survival assay
Cytotoxicity against RECQL5 knock out human MCF7 cells assessed as inhibition of colony formation measured after 8 to 10 days by clonogenic survival assay
[PMID: 33529023]
MCF7 IC50
4.8 μM
Compound: 4a
Cytotoxicity against human MCF7 cells expressing wild type RECQL5 assessed as inhibition of colony formation measured after 8 to 10 days by clonogenic survival assay
Cytotoxicity against human MCF7 cells expressing wild type RECQL5 assessed as inhibition of colony formation measured after 8 to 10 days by clonogenic survival assay
[PMID: 33529023]
Molecular Weight

552.49

Formula

C25H18F6N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(N[C@@H](C2=CC=CC=C2)C3=NN=C(SCC4=CC=CC=C4)O3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (452.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8100 mL 9.0499 mL 18.0999 mL
5 mM 0.3620 mL 1.8100 mL 3.6200 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8100 mL 9.0499 mL 18.0999 mL 45.2497 mL
5 mM 0.3620 mL 1.8100 mL 3.6200 mL 9.0499 mL
10 mM 0.1810 mL 0.9050 mL 1.8100 mL 4.5250 mL
15 mM 0.1207 mL 0.6033 mL 1.2067 mL 3.0166 mL
20 mM 0.0905 mL 0.4525 mL 0.9050 mL 2.2625 mL
25 mM 0.0724 mL 0.3620 mL 0.7240 mL 1.8100 mL
30 mM 0.0603 mL 0.3017 mL 0.6033 mL 1.5083 mL
40 mM 0.0452 mL 0.2262 mL 0.4525 mL 1.1312 mL
50 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9050 mL
60 mM 0.0302 mL 0.1508 mL 0.3017 mL 0.7542 mL
80 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5656 mL
100 mM 0.0181 mL 0.0905 mL 0.1810 mL 0.4525 mL
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RECQL5-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RECQL5-IN-12718170-45-5DNA/RNA SynthesisOthersRECQL5Breast Cancerorally effectiveInhibitorinhibitorinhibit

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