2. Protein Tyrosine Kinase/RTK Autophagy MAPK/ERK Pathway
  3. VEGFR Autophagy PDGFR Raf RET
  4. Regorafenib-d3

Regorafenib-d3  (Synonyms: BAY 73-4506-d3)

Cat. No.: HY-10331S Purity: ≥98.0%
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Regorafenib-d3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].

For research use only. We do not sell to patients.

Regorafenib-d<sub>3</sub> Chemical Structure

Regorafenib-d3 Chemical Structure

CAS No. : 1255386-16-3

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1 mg USD 827 In-stock
5 mg USD 2650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Regorafenib-d3:

Regorafenib-d3 Related Antibodies

Top Publications Citing Use of Products

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PDGFR PDGFRβ PDGFRα

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BRaf c-Raf Raf

  • Biological Activity

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Description

Regorafenib-d3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].

Molecular Weight

485.83

Formula

C21H12D3ClF4N4O3
CAS No.
Unlabeled CAS

755037-03-7
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=C1)NC([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (257.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 125 mg/mL (257.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0583 mL 10.2917 mL 20.5833 mL
5 mM 0.4117 mL 2.0583 mL 4.1167 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.0583 mL 10.2917 mL 20.5833 mL 51.4583 mL
5 mM 0.4117 mL 2.0583 mL 4.1167 mL 10.2917 mL
10 mM 0.2058 mL 1.0292 mL 2.0583 mL 5.1458 mL
15 mM 0.1372 mL 0.6861 mL 1.3722 mL 3.4306 mL
20 mM 0.1029 mL 0.5146 mL 1.0292 mL 2.5729 mL
25 mM 0.0823 mL 0.4117 mL 0.8233 mL 2.0583 mL
30 mM 0.0686 mL 0.3431 mL 0.6861 mL 1.7153 mL
40 mM 0.0515 mL 0.2573 mL 0.5146 mL 1.2865 mL
50 mM 0.0412 mL 0.2058 mL 0.4117 mL 1.0292 mL
60 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8576 mL
80 mM 0.0257 mL 0.1286 mL 0.2573 mL 0.6432 mL
100 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5146 mL
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Regorafenib-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Regorafenib-d31255386-16-3BAY 73-4506-d3VEGFRAutophagyPDGFRRafRETVascular endothelial growth factor receptorPlatelet-derived growth factor receptorRaf kinasesVEGFR1/2/3PDGFRβKitRaf-1Inhibitorinhibitorinhibit

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