2. Apoptosis Cell Cycle/DNA Damage
  3. CDK Bcl-2 Family c-Myc
  4. rel-AZ5576

rel-AZ5576 is a selective CDK9 inhibitor with the activity of downregulating Mcl-1 and MYC mRNA transcription and protein expression in diffuse large B-cell lymphoma by inhibiting CDK9, promoting MYC protein turnover, reducing MYC phosphorylation on the stable Ser62 residue and downregulating MYC transcriptional targets, inhibiting the growth of diffuse large B-cell lymphoma cell lines in vitro and in vivo and independent of the cell origin.

For research use only. We do not sell to patients.

rel-AZ5576 Chemical Structure

rel-AZ5576 Chemical Structure

CAS No. : 1333468-05-5

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rel-AZ5576 Related Antibodies

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Description

rel-AZ5576 is a selective CDK9 inhibitor with the activity of downregulating Mcl-1 and MYC mRNA transcription and protein expression in diffuse large B-cell lymphoma by inhibiting CDK9, promoting MYC protein turnover, reducing MYC phosphorylation on the stable Ser62 residue and downregulating MYC transcriptional targets, inhibiting the growth of diffuse large B-cell lymphoma cell lines in vitro and in vivo and independent of the cell origin.

Molecular Weight

385.43

Formula

C21H24FN3O3
CAS No.
SMILES

O=C([C@H]1C[C@@H](NC(C)=O)CCC1)NC2=NC=CC(C3=CC=C(F)C=C3OC)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (518.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5945 mL 12.9725 mL 25.9450 mL
5 mM 0.5189 mL 2.5945 mL 5.1890 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5945 mL 12.9725 mL 25.9450 mL 64.8626 mL
5 mM 0.5189 mL 2.5945 mL 5.1890 mL 12.9725 mL
10 mM 0.2595 mL 1.2973 mL 2.5945 mL 6.4863 mL
15 mM 0.1730 mL 0.8648 mL 1.7297 mL 4.3242 mL
20 mM 0.1297 mL 0.6486 mL 1.2973 mL 3.2431 mL
25 mM 0.1038 mL 0.5189 mL 1.0378 mL 2.5945 mL
30 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1621 mL
40 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6216 mL
50 mM 0.0519 mL 0.2595 mL 0.5189 mL 1.2973 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0810 mL
80 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.8108 mL
100 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.6486 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

rel-AZ55761333468-05-5CDKBcl-2 Familyc-MycCyclin dependent kinaseMycInhibitorinhibitorinhibit

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