2. Protein Tyrosine Kinase/RTK
  3. RET
  4. RET-IN-7

RET-IN-7 demonstrates potent in vitro RET kinase inhibition and robust in vivo efficacy in RET-driven tumor xenografts upon multiday dosing in mice.

For research use only. We do not sell to patients.

RET-IN-7 Chemical Structure

RET-IN-7 Chemical Structure

CAS No. : 2763386-05-4

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5 mg USD 650 In-stock
10 mg USD 1050 In-stock
25 mg USD 1995 In-stock
50 mg USD 3200 In-stock
100 mg USD 5100 In-stock
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Based on 1 publication(s) in Google Scholar

RET-IN-7 Related Antibodies

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Description

RET-IN-7 demonstrates potent in vitro RET kinase inhibition and robust in vivo efficacy in RET-driven tumor xenografts upon multiday dosing in mice.

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
4.1 μM
Compound: 1
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
[PMID: 34917254]
Molecular Weight

458.92

Formula

C22H24ClFN6O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC12CCC(CC1)(CC2)N3C=C(C4=C3N=CN=C4N)C5=C(F)C=C(Cl)C(N)=C5)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (36.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1790 mL 10.8951 mL 21.7903 mL
5 mM 0.4358 mL 2.1790 mL 4.3581 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1790 mL 10.8951 mL 21.7903 mL 54.4757 mL
5 mM 0.4358 mL 2.1790 mL 4.3581 mL 10.8951 mL
10 mM 0.2179 mL 1.0895 mL 2.1790 mL 5.4476 mL
15 mM 0.1453 mL 0.7263 mL 1.4527 mL 3.6317 mL
20 mM 0.1090 mL 0.5448 mL 1.0895 mL 2.7238 mL
25 mM 0.0872 mL 0.4358 mL 0.8716 mL 2.1790 mL
30 mM 0.0726 mL 0.3632 mL 0.7263 mL 1.8159 mL
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RET-IN-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-72763386-05-4RETInhibitorinhibitorinhibit

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HY-141896
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