RETF-4NA

Cat. No.: HY-P1347: Data Sheet Handling Instructions Technical Support

RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RETF-4NA Chemical Structure

CAS No. : 1160928-63-1

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Other Forms of RETF-4NA:

RETF-4NA TFA Get quote

Biological Activity
Purity & Documentation
References
Customer Review

Description

RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M^[1]^[2].

Molecular Weight

713.74

Formula

C₃₂H₄₃N₉O₁₀

CAS No.

1160928-63-1

Sequence

Ac-Arg-Glu-Thr-Phe-pNA

Sequence Shortening

Ac-RETF-pNA

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Data Sheet (268 KB) Handling Instructions (2659 KB)

References

[1]. Wilfred W Raymond, et al. Alpha 2-macroglobulin Capture Allows Detection of Mast Cell Chymase in Serum and Creates a Reservoir of Angiotensin II-generating Activity. J Immunol. 2009 May 1;182(9):5770-7. [Content Brief]

[2]. Katariina Maaninka, et al. Human Mast Cells Arise From a Common Circulating Progenitor. J Allergy Clin Immunol. 2013 Aug;132(2):463-9.e3. [Content Brief]

RETF-4NA Related Classifications

Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Keywords:

RETF-4NA1160928-63-1Biochemical Assay ReagentsInhibitorinhibitorinhibit

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RETF-4NA

Other Forms of RETF-4NA:

Biological Activity

Purity & Documentation

References

Customer Review

RETF-4NA Related Classifications

Molarity Calculator

Dilution Calculator