Vitamin A-d₈  (Synonyms: Vitamin A1-d₈; all-trans-Retinol-d₈)

Vitamin A-d₈ is the deuterium labeled Vitamin A. Vitamin A is an endogenous metabolite.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

294.50

C₂₀H₂₂D₈O

212848-81-2

68-26-8

Oil

Light yellow to yellow

CC1=C(/C=C/C(C([2H])([2H])[2H])=C(/C=C/C(C([2H])([2H])[2H])=C(CO)\[2H])[2H])C(C)(C)CCC1

Shipping with dry ice.

-80°C, protect from light, stored under nitrogen

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Zhang M, et al. High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats. J Pharmacol Sci. 2015 Apr;127(4):430-8.;Miyazaki H, et al. Retinol status and expression of retinol-related proteins in  [Content Brief]