Retinol-d4  (Synonyms: Vitamin A1-d4; all-trans-Retinol-d4)

Retinol-d₄ (Vitamin A1-d₄; all-trans-Retinol-d₄) is the deuterium labeled Vitamin A. Retinol is an endogenous metabolite.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

290.48

C₂₀H₂₆D₄O

118063-12-0

68-26-8

Oil

Colorless to light yellow

C(=C/C(=C(/C=C/C(=C/CO)/C)\[2H])/C([2H])([2H])[2H])\C=1C(C)(C)CCCC1C

Shipping with dry ice.

-80°C, protect from light, stored under nitrogen

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Zhang M, et al. High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats. J Pharmacol Sci. 2015 Apr;127(4):430-8.  [Content Brief]

  [3]. Miyazaki H, et al. Retinol status and expression of retinol-related proteins in methionine-choline deficient rats. J Nutr Sci Vitaminol (Tokyo). 2014;60(2):78-85.  [Content Brief]