2. Membrane Transporter/Ion Channel
  3. Aquaporin
  4. RG100204

RG100204 is an orally active AQP9 inhibitor with anti-inflammatory activity. RG100204 can alleviate sepsis-induced cardiac dysfunction (both systolic and diastolic), improve renal dysfunction, and reduce the elevation of LDH, a marker of cellular injury.

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RG100204 Chemical Structure

RG100204 Chemical Structure

CAS No. : 2140901-88-6

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Based on 1 publication(s) in Google Scholar

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Description

RG100204 is an orally active AQP9 inhibitor with anti-inflammatory activity. RG100204 can alleviate sepsis-induced cardiac dysfunction (both systolic and diastolic), improve renal dysfunction, and reduce the elevation of LDH, a marker of cellular injury[1].

Molecular Weight

446.59

Formula

C20H26N6O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)OC1=CC=C(C2=NN=C(NC(CSC3=NN=C(C(C)C)N3CC)=O)S2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2392 mL 11.1960 mL 22.3919 mL
5 mM 0.4478 mL 2.2392 mL 4.4784 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2392 mL 11.1960 mL 22.3919 mL 55.9798 mL
5 mM 0.4478 mL 2.2392 mL 4.4784 mL 11.1960 mL
10 mM 0.2239 mL 1.1196 mL 2.2392 mL 5.5980 mL
15 mM 0.1493 mL 0.7464 mL 1.4928 mL 3.7320 mL
20 mM 0.1120 mL 0.5598 mL 1.1196 mL 2.7990 mL
25 mM 0.0896 mL 0.4478 mL 0.8957 mL 2.2392 mL
30 mM 0.0746 mL 0.3732 mL 0.7464 mL 1.8660 mL
40 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3995 mL
50 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1196 mL
60 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9330 mL
80 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6997 mL
100 mM 0.0224 mL 0.1120 mL 0.2239 mL 0.5598 mL
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RG100204 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG1002042140901-88-6RG 100204RG-100204AquaporinAQPSepsiscardiac dysfunctionrenal dysfunctionCHOFaO hepatoma cellsanti-inflammatory activityInhibitorinhibitorinhibit

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