2. Cell Cycle/DNA Damage
  3. CDK
  4. Ribociclib-d6 hydrochloride

Ribociclib-d6 hydrochloride  (Synonyms: LEE011-d6 hydrochloride)

Cat. No.: HY-15777AS Purity: 99.24%
SDS COA Handling Instructions

Molarity Calculator

Ribociclib-d6 (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

For research use only. We do not sell to patients.

Ribociclib-d<sub>6</sub> hydrochloride Chemical Structure

Ribociclib-d6 hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Ribociclib-d6 hydrochloride:

Ribociclib-d6 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ribociclib-d6 (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

Molecular Weight

477.04

Formula

C23H25D6ClN8O
Unlabeled CAS

1211443-80-9
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (209.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0963 mL 10.4813 mL 20.9626 mL
5 mM 0.4193 mL 2.0963 mL 4.1925 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

SDS (788 KB)

COA (250 KB) HNMR (306 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.0963 mL 10.4813 mL 20.9626 mL 52.4065 mL
5 mM 0.4193 mL 2.0963 mL 4.1925 mL 10.4813 mL
10 mM 0.2096 mL 1.0481 mL 2.0963 mL 5.2407 mL
15 mM 0.1398 mL 0.6988 mL 1.3975 mL 3.4938 mL
20 mM 0.1048 mL 0.5241 mL 1.0481 mL 2.6203 mL
25 mM 0.0839 mL 0.4193 mL 0.8385 mL 2.0963 mL
30 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.7469 mL
40 mM 0.0524 mL 0.2620 mL 0.5241 mL 1.3102 mL
50 mM 0.0419 mL 0.2096 mL 0.4193 mL 1.0481 mL
60 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8734 mL
80 mM 0.0262 mL 0.1310 mL 0.2620 mL 0.6551 mL
100 mM 0.0210 mL 0.1048 mL 0.2096 mL 0.5241 mL
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Ribociclib-d6 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ribociclib-d6LEE011-d6CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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