2. Cell Cycle/DNA Damage
  3. CDK
  4. Ribociclib-d8

Ribociclib-d8  (Synonyms: LEE011-d8)

Cat. No.: HY-15777S1 Purity: 99.23%
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Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].

For research use only. We do not sell to patients.

Ribociclib-d<sub>8</sub> Chemical Structure

Ribociclib-d8 Chemical Structure

CAS No. : 2167898-24-8

Size Price Stock Quantity
100 μg USD 75 In-stock
1 mg USD 310 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ribociclib-d8:

Ribociclib-d8 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ribociclib-d8 Related Antibodies
Molecular Weight

442.59

Formula

C23H22D8N8O
CAS No.
Unlabeled CAS

1211441-98-3
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C)C(C(N(C1CCCC1)C2=N3)=CC2=CN=C3NC4=CC=C(N5C([2H])([2H])C([2H])([2H])NC([2H])([2H])C5([2H])[2H])C=N4)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (225.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2594 mL 11.2971 mL 22.5943 mL
5 mM 0.4519 mL 2.2594 mL 4.5189 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2594 mL 11.2971 mL 22.5943 mL 56.4857 mL
5 mM 0.4519 mL 2.2594 mL 4.5189 mL 11.2971 mL
10 mM 0.2259 mL 1.1297 mL 2.2594 mL 5.6486 mL
15 mM 0.1506 mL 0.7531 mL 1.5063 mL 3.7657 mL
20 mM 0.1130 mL 0.5649 mL 1.1297 mL 2.8243 mL
25 mM 0.0904 mL 0.4519 mL 0.9038 mL 2.2594 mL
30 mM 0.0753 mL 0.3766 mL 0.7531 mL 1.8829 mL
40 mM 0.0565 mL 0.2824 mL 0.5649 mL 1.4121 mL
50 mM 0.0452 mL 0.2259 mL 0.4519 mL 1.1297 mL
60 mM 0.0377 mL 0.1883 mL 0.3766 mL 0.9414 mL
80 mM 0.0282 mL 0.1412 mL 0.2824 mL 0.7061 mL
100 mM 0.0226 mL 0.1130 mL 0.2259 mL 0.5649 mL
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Ribociclib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ribociclib-d82167898-24-8LEE011-d8CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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