2. Immunology/Inflammation
  3. Interleukin Related
  4. Risankizumab

Risankizumab  (Synonyms: Risankizumab rzaa; BI 655066)

Cat. No.: HY-P99248 Purity: 99.37%
COA

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Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis.

For research use only. We do not sell to patients.

CAS No. : 1612838-76-2

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Based on 1 publication(s) in Google Scholar

Risankizumab Related Antibodies

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Description

Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target[3]

IL-23

<10 pM (Kd)

In Vitro

Risankizumab (BI 655066) has a high affinity for human and cynomolgus IL23 with Kds <10 pM[3].
Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Risankizumab Related Antibodies
In Vivo

Risankizumab (BI 655066) (1 mg/kg; i.p.; single dosage) inhibits IL23-induced mice ear swelling and cytokine production[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (injected with BI 655066, 1 h later injected recombinant human IL23 into the skin of the mouse ear for 4 days)[3]
Dosage: 1 mg/kg
Administration: i.p.; single dosage
Result: Significantly inhibited IL23-induced ear swelling and cytokine production.
Animal Model: Cynomolgus monkeys[3]
Dosage: 1.0 mg/kg
Administration: i.v. or s.c.
Result: Pharmacokinetic Parameters of Risankizumab (BI 655066) in cynomolgus monkeys[1].
IV (1 mg/kg) SC (1 mg/kg)
AUCinf (μg·day/mL) 202 ± 33.5 142 ± 33.3
CL (mL/day/kg) 5.18 ± 0.8 /
Vd, ss (mL/kg) 88.3 ± 3.12 /
t1/2 (h) 12.2 ± 2.28/ 9.15 ± 1.87
Cmax (μg/mL) / 10.1 ± 3.14
Tmax (day) / 2.11 ± 1.84
F (%) / 70.4 ± 16.5
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Risankizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 99.37%

COA (231 KB) SDS-PAGE (79 KB) SEC-HPLC (88 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Risankizumab Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Risankizumab1612838-76-2Risankizumab rzaa BI 655066BI655066BI 655066BI-655066Interleukin RelatedILIL-23psoriasisswellingcytokineCynomolgus monkeysInhibitorinhibitorinhibit

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