2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. RKI-1313

RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 µM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth.

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RKI-1313 Chemical Structure

RKI-1313 Chemical Structure

CAS No. : 1342276-76-9

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RKI-1313 Related Antibodies

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ROCK ROCK1 ROCK2

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Description

RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 µM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1].

IC50 & Target[1]

ROCK1

34 μM (IC50)

ROCK2

8 μM (IC50)

Molecular Weight

340.40

Formula

C17H16N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=CC(CNC(NC2=NC(C3=CC=NC=C3)=CS2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (88.13 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9377 mL 14.6886 mL 29.3772 mL
5 mM 0.5875 mL 2.9377 mL 5.8754 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.2%

SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9377 mL 14.6886 mL 29.3772 mL 73.4430 mL
5 mM 0.5875 mL 2.9377 mL 5.8754 mL 14.6886 mL
10 mM 0.2938 mL 1.4689 mL 2.9377 mL 7.3443 mL
15 mM 0.1958 mL 0.9792 mL 1.9585 mL 4.8962 mL
20 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL
25 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9377 mL
30 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4481 mL
40 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4689 mL
60 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
80 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
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RKI-1313 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RKI-13131342276-76-9RKI1313RKI 1313ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKMDA-MB-231 cellsROCK substratesmigrationanticancerInhibitorinhibitorinhibit

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