2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. RNase L-IN-2

RNase L-IN-2 (compound 2) is an activtor of RNase L with EC50 value of 22 μM.

For research use only. We do not sell to patients.

RNase L-IN-2 Chemical Structure

RNase L-IN-2 Chemical Structure

CAS No. : 357618-26-9

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Based on 1 publication(s) in Google Scholar

RNase L-IN-2 Related Antibodies

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Description

RNase L-IN-2 (compound 2) is an activtor of RNase L with EC50 value of 22 μM[1].

Molecular Weight

298.36

Formula

C16H14N2O2S
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C1C(C2=C(CCCC2)S3)=C3NC(C4=CC=CC(O)=C4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 5.56 mg/mL (18.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3517 mL 16.7583 mL 33.5166 mL
5 mM 0.6703 mL 3.3517 mL 6.7033 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMF    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.56 mg/mL (1.88 mM); Clear solution

  • Protocol 2

    Add each solvent one by one:  10% DMF    90% Corn Oil

    Solubility: ≥ 0.56 mg/mL (1.88 mM); Clear solution

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 3.3517 mL 16.7583 mL 33.5166 mL 83.7914 mL
5 mM 0.6703 mL 3.3517 mL 6.7033 mL 16.7583 mL
10 mM 0.3352 mL 1.6758 mL 3.3517 mL 8.3791 mL
15 mM 0.2234 mL 1.1172 mL 2.2344 mL 5.5861 mL
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RNase L-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RNase L-IN-2357618-26-9DNA/RNA SynthesisRNase LInhibitorinhibitorinhibit

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