ROCK2-IN-8

Cat. No.: HY-116420 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC₅₀ of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation.

For research use only. We do not sell to patients.

ROCK2-IN-8 Chemical Structure

CAS No. : 681173-76-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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ROCK ROCK1 ROCK2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A7R5	IC₅₀	0.137 μM Compound: 1	Inhibition of myosin light chain bisphosphorylation in rat A7r5 cells after 1 hr Inhibition of myosin light chain bisphosphorylation in rat A7r5 cells after 1 hr	[PMID: 18834107]

Molecular Weight

339.37

Formula

C₁₇H₁₃N₃O₃S

CAS No.

681173-76-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1OC2=C(OC1)C=CC=C2)NC3=NC(C4=CC=NC=C4)=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (14.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9466 mL	14.7332 mL	29.4664 mL
5 mM	0.5893 mL	2.9466 mL	5.8933 mL
10 mM	0.2947 mL	1.4733 mL	2.9466 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (242 KB) RP-HPLC (378 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9466 mL	14.7332 mL	29.4664 mL	73.6659 mL
	5 mM	0.5893 mL	2.9466 mL	5.8933 mL	14.7332 mL
	10 mM	0.2947 mL	1.4733 mL	2.9466 mL	7.3666 mL

ROCK2-IN-8 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK2-IN-8681173-76-2ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKorally activeaqueous humormyosinlight chainphosphorylationInhibitorinhibitorinhibit

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