Ropinirole  (Synonyms: SKF 101468)

Ropinirole (SKF 101468) is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole has no affinity for the D₁ receptors. Ropinirole has the potential for Parkinson's disease^[1][2].

Ropinirole has affinity for D₃ receptors of 10-20 fold higher than the D₂ and D₄ receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT₂ receptors but inactive at 5-HT₁, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

260.37

C₁₆H₂₄N₂O

91374-21-9

O=C1NC2=C(C(CCN(CCC)CCC)=CC=C2)C1

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• [1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54.  [Content Brief]

  [2]. Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93.  [Content Brief]