2. Autophagy Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Anti-infection Others
  3. Autophagy Potassium Channel Bacterial HMG-CoA Reductase (HMGCR) Isotope-Labeled Compounds
  4. Rosuvastatin-13C,d3 sodium

Rosuvastatin-13C,d3 sodium  (Synonyms: ZD 4522-13C,d3 sodium; X-Plended-13C,d3 sodium; Crestor-13C,d3 sodium)

Cat. No.: HY-17504BS2
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Rosuvastatin-13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

For research use only. We do not sell to patients.

Rosuvastatin-<sub>13</sub>C,d<sub>3</sub> sodium Chemical Structure

Rosuvastatin-13C,d3 sodium Chemical Structure

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Rosuvastatin-13C,d3 sodium Related Antibodies

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Description

Rosuvastatin-13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rosuvastatin-13C,d3 sodium Related Antibodies
In Vivo

Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[3].
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Sodium (VLDL) in diabetes mellitus rats induced by Streptozocin[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

507.53

Formula

C2113CH24D3FN3NaO6S
Unlabeled CAS

147098-18-8
SMILES

O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N([13C]([2H])([2H])[2H])S(=O)(C)=O)N=C1C2=CC=C(C=C2)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Rosuvastatin-13C,d3 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosuvastatin-13C,d3ZD 4522-13C,d3X-Plended-13C,d3Crestor-13C,d3AutophagyPotassium ChannelBacterialHMG-CoA Reductase (HMGCR)Isotope-Labeled CompoundsKcsAhERGcardiacrepolarizationactionpotentialdurationsAPDsQTQTcHsp70low-densitylipoproteincholesteroltriglyceridesInhibitorinhibitorinhibit

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