2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. RuBi-GABA

RuBi-GABA is a new ruthenium-based caged GABA compound. RuBi-GABA photocleaves and releases GABA after being excited with visible wavelengths. RuBi-GABA produces gaba receptor-mediated currents.

For research use only. We do not sell to patients.

RuBi-GABA Chemical Structure

RuBi-GABA Chemical Structure

CAS No. : 1028141-88-9

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Based on 1 publication(s) in Google Scholar

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Description

RuBi-GABA is a new ruthenium-based caged GABA compound. RuBi-GABA photocleaves and releases GABA after being excited with visible wavelengths. RuBi-GABA produces gaba receptor-mediated currents[1].

Molecular Weight

922.80

Formula

C42H39F6N5O2P2Ru
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

[O-]C(CCC[NH2][Ru+2]12([N]3=CC=CC=C3C4=CC=CC=[N]14)([N]5=CC=CC=C5C6=CC=CC=[N]26)[P](C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9)=O.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (108.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0837 mL 5.4183 mL 10.8366 mL
5 mM 0.2167 mL 1.0837 mL 2.1673 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0837 mL 5.4183 mL 10.8366 mL 27.0915 mL
5 mM 0.2167 mL 1.0837 mL 2.1673 mL 5.4183 mL
10 mM 0.1084 mL 0.5418 mL 1.0837 mL 2.7091 mL
15 mM 0.0722 mL 0.3612 mL 0.7224 mL 1.8061 mL
20 mM 0.0542 mL 0.2709 mL 0.5418 mL 1.3546 mL
25 mM 0.0433 mL 0.2167 mL 0.4335 mL 1.0837 mL
30 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9030 mL
40 mM 0.0271 mL 0.1355 mL 0.2709 mL 0.6773 mL
50 mM 0.0217 mL 0.1084 mL 0.2167 mL 0.5418 mL
60 mM 0.0181 mL 0.0903 mL 0.1806 mL 0.4515 mL
80 mM 0.0135 mL 0.0677 mL 0.1355 mL 0.3386 mL
100 mM 0.0108 mL 0.0542 mL 0.1084 mL 0.2709 mL
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RuBi-GABA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RuBi-GABA1028141-88-9GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorruthenium-based cagedGABAvisible wavelengthscurrentsInhibitorinhibitorinhibit

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