RX 67668 

RX 67668 is a potent cholinesterase inhibitor with an IC₅₀ of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue^[1][2].

IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase)^[1]

RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value^[1].
Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

265.82

C₁₆H₂₄ClN

40709-76-0

[H]Cl.N1([C@H]2[C@@H](C3=CC=CC=C3)CCCC2)CCCC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Doxey JC, et al. Some pharmacological properties of RX 67668--a new anticholinesterase. Br J Pharmacol. 1972 Nov;46(3):568P-569P.  [Content Brief]

  [2]. Metcalf G, wt al. Evaluation of RX 72601 as an anti-curare agent. Br J Anaesth. 1975 Apr;47(4):451-6.  [Content Brief]