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2-benzofuran-2-yl-2-imidazoline-d4-hydrochloride

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Imidazoline Receptor (26) 5-HT Receptor (3) Adrenergic Receptor (20) Androgen Receptor (1) Apoptosis (5) Autophagy (7) Bacterial (1) Biochemical Assay Reagents (2) Calcium Channel (1) Calmodulin (1) CDK (1) CRFR (1) Dopamine Receptor (1) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (1) FKBP (1) Fluorescent Dye (1) GABA Receptor (1) Glucosylceramide Synthase (GCS) (1) Histamine Receptor (1) HIV (1) Insulin Receptor (1) Isotope-Labeled Compounds (4) Ligands for Target Protein for PROTAC (1) mAChR (1) MAP4K (1) Monoamine Oxidase (4) mTOR (1) nAChR (1) Necroptosis (1) NO Synthase (1) Opioid Receptor (1) PCSK9 (1) PI3K (1) Potassium Channel (3) PROTACs (1) Reactive Oxygen Species (1) SARS-CoV (1) TNF Receptor (1) Transthyretin (TTR) (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (18) Endocrinology (5) Infection (5) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (30)

By Targets:

Imidazoline Receptor (26)

5-HT Receptor (3)

Adrenergic Receptor (20)

Androgen Receptor (1)

Apoptosis (5)

Autophagy (7)

Bacterial (1)

Biochemical Assay Reagents (2)

Calcium Channel (1)

Calmodulin (1)

CDK (1)

CRFR (1)

Dopamine Receptor (1)

Drug Metabolite (1)

EGFR (1)

Endogenous Metabolite (1)

FKBP (1)

Fluorescent Dye (1)

GABA Receptor (1)

Glucosylceramide Synthase (GCS) (1)

Histamine Receptor (1)

HIV (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (4)

Ligands for Target Protein for PROTAC (1)

mAChR (1)

MAP4K (1)

Monoamine Oxidase (4)

mTOR (1)

nAChR (1)

Necroptosis (1)

NO Synthase (1)

Opioid Receptor (1)

PCSK9 (1)

PI3K (1)

Potassium Channel (3)

PROTACs (1)

Reactive Oxygen Species (1)

SARS-CoV (1)

TNF Receptor (1)

Transthyretin (TTR) (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (18)

Endocrinology (5)

Infection (5)

Inflammation/Immunology (5)

Metabolic Disease (5)

Neurological Disease (30)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Imidazoline Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W004801

Benzofuran-3-carbaldehyde	Others	Others
Benzofuran-3-carbaldehyde is a bioactive chemical, and can be used for the synthesis of active compound .

HY-B1416A

Efaroxan hydrochloride	Adrenergic Receptor Imidazoline Receptor	Cardiovascular Disease Metabolic Disease
Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective *I1-Imidazoline* receptor** antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease .

HY-141714

SBC-115337	PCSK9	Cancer
SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC₅₀ value of 0.5 μM .

HY-B1800

Tolonidine	Others	Cardiovascular Disease
Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties .

HY-N1352

Rhuscholide A	HIV	Infection
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM .

HY-N8750

5-Acetyl-2-(1-hydroxy-1-methylethyl)benzofuran	Others	Others
5-Acetyl-2-(1-hydroxy-1-methylethyl)benzofuran serves as a phytoalexin.

HY-N7724

Cedrusin (+)-Cedrusin	Others	Others
Cedrusin is a benzofuran derivative that can be isolated from Styrax suberifolius .

HY-N12991

Picraquassioside B	Others	Others
Picraquassioside B is a benzofuran glucosides and can isolated from Cnidium monnieri fruits .

HY-N9224

5-Acetyl-6-hydroxy-2-(1-hydroxy-1-methylethyl)benzofuran	Others	Others
5-Acetyl-6-hydroxy-2-(1-hydroxy-1-methylethyl)benzofuran is a Phenols product that can be isolated from the herbs of Artemisia dracunculus. .

HY-101374A

AGN 192403 hydrochloride BRD4780 hydrochloride	Imidazoline Receptor	Cardiovascular Disease Neurological Disease
AGN 192403 (BRD4780) hydrochloride is an *I1-Imidazoline* receptor** antagonist for cardiovascular and neurological research .

HY-B1800R

Tolonidine (Standard)	Others	Cardiovascular Disease
Tolonidine (Standard) is the analytical standard of Tolonidine. This product is intended for research and analytical applications. Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties .

HY-106207

Celivarone SSR149744C	Others	Cardiovascular Disease
Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research .

HY-W348072

SARS-CoV-2-IN-59	SARS-CoV	Infection
SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule inhibitor of SARS-CoV-2 that targets the main protease (Mpro) of the coronavirus. SARS-CoV-2-IN-59 has a strong interaction with residues on Mpro (Met 165, Gln 166, Met 165, His 41, Gln 189) .

HY-14188

Amiodarone hydrochloride Maximum Cited Publications 9 Publications Verification	Potassium Channel Autophagy	Cardiovascular Disease Cancer
Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC₅₀ of ∼45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .

HY-W004116

2-Benzofurylboronic acid	Biochemical Assay Reagents	Others
Benzofuran-2-boronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N7503

Psoralenoside	Histamine Receptor Calcium Channel Calmodulin	Infection Metabolic Disease Cancer
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-101170

BU224 hydrochloride	Imidazoline Receptor Apoptosis TNF Receptor	Neurological Disease Inflammation/Immunology
BU224 hydrochloride is a selective and high affinity imidazoline I₂ receptor ligand, with a K_i of 2.1 nM. BU224 hydrochloride is sometimes used as an I₂ receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research .

HY-N3805

Encecalin	Others	Others
Encecalin is a natural benzofuran compound .

HY-13250B

Silvestrol aglycone (enantiomer)	Others	Cancer
Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol .

HY-D1760

SBFI Sodium-binding benzofuran isophthalate	Fluorescent Dye	Others
SBFI is a membrane-permeant, fluorescent Na ⁺ indicator dye. SBFI is excited at 340 nm and the fluorophore emission is collected at 450 nm . SBFI selective for Na ⁺ over K ⁺ with K_d values of 20 and 120 mM for these ions, respectively. .

HY-W001165

3-Coumaranone benzofuran-3-one	Biochemical Assay Reagents	Others
3-Coumaranone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B0374A

Moxonidine hydrochloride BDF5895 hydrochloride	Imidazoline Receptor	Neurological Disease
Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

HY-B0374

Moxonidine BDF5895	Imidazoline Receptor	Neurological Disease
Moxonidine(BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

HY-N4161

Euparin	Reactive Oxygen Species	Infection Neurological Disease
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-14561A

Idazoxan hydrochloride RX 781094 hydrochloride	Adrenergic Receptor Imidazoline Receptor	Neurological Disease Endocrinology
Idazoxan hydrochloride (RX 781094 hydrochloride) is an α₂-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism .

HY-15481

KU14R	Insulin Receptor	Metabolic Disease Endocrinology
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.

HY-106504

Aganodine	Imidazoline Receptor	Neurological Disease
Aganodine is a guanidine that activates presynaptic imidazoline receptors and can inhibit electrically evoked [ ³H]-norepinephrine release .

HY-B0556A

Tetrahydrozoline hydrochloride Tetryzoline hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion .

HY-B0556

Tetrahydrozoline Tetryzoline	Adrenergic Receptor	Cardiovascular Disease
Tetrahydrozoline (Tetryzoline), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion .

HY-101238

Agmatine sulfate	Imidazoline Receptor NO Synthase Endogenous Metabolite	Neurological Disease Cancer
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

HY-B0556B

Tetrahydrozoline nitrate Tetryzoline nitrate	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
Tetrahydrozoline (Tetryzoline) nitrate , a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion .

HY-N7504

Isopsoralenoside	Bacterial	Infection Metabolic Disease Cancer
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-101380A

BU226 hydrochloride	Imidazoline Receptor	Neurological Disease
BU226 hydrochloride is a selective imidazoline 2 (I₂) receptors ligand with an K_i of 1.4 nM for I₂ and an IC₅₀ of 534.5 nM for I₁. BU226 hydrochloride can be used for researching antidepressant .

HY-103425

JHW007 hydrochloride	Dopamine Receptor	Neurological Disease
JHW007 hydrochloride is the hydrochloride of JHW007. JHW007 is an antagonist of cocaine .

HY-145514C

dTAGV-1 hydrochloride	FKBP PROTACs	Cancer
dTAGV-1 hydrochloride is the hydrochloride form of dTAGV-1 that is a small molecule degrader of FKBP12 .

HY-B0374R

Moxonidine (Standard)	Imidazoline Receptor	Neurological Disease
Moxonidine (Standard) is the analytical standard of Moxonidine. This product is intended for research and analytical applications. Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-B0374S1

Moxonidine-d7 BDF5895-d₇	Imidazoline Receptor Isotope-Labeled Compounds	Neurological Disease
Moxonidine-d₇ is deuterated labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-113985

Cirazoline LD 3098	Imidazoline Receptor Adrenergic Receptor	Neurological Disease
Cirazoline (LD 3098) is a doul agonist of Presynaptic imidazoline receptors (R(i-pre)) and α-adrenoceptor (R(α)). Cirazoline (30 μM) suppresses M current in SCG neurons cultured overnight .

HY-B0556AS

Tetrahydrozoline-d4 hydrochloride Tetryzoline-d₄ (hydrochloride)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tetrahydrozoline-d₄ (hydrochloride) is the deuterium labeled Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

HY-B0374S

Moxonidine-d4	Imidazoline Receptor	Neurological Disease
Moxonidine-d₄ (BDF5895-d4) is the deuterium labeled Moxonidine. Moxonidine(BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent[1][2].

HY-B0556R

Tetrahydrozoline (Standard)	Adrenergic Receptor	Cardiovascular Disease
Tetrahydrozoline (Standard) is the analytical standard of Tetrahydrozoline. This product is intended for research and analytical applications. Tetrahydrozoline (Tetryzoline), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion .

HY-B0556AR

Tetrahydrozoline hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Tetrahydrozoline (hydrochloride) (Standard) is the analytical standard of Tetrahydrozoline (hydrochloride). This product is intended for research and analytical applications. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion .

HY-14561

Idazoxan RX 781094	Adrenergic Receptor Imidazoline Receptor	Neurological Disease
Idazoxan (RX 781094) is a potent antagonist of α2 adrenergic receptor (α2AR) and potential I2 imidazoline receptor agonist. Idazoxan can be used in the research of antidepression and schizophrenia. Idazoxan has oral bioactivity .

HY-101392S

Harmane-d1	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S1

Harmane-d2	Isotope-Labeled Compounds Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor	Neurological Disease Cancer
Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-N1777

3,4-Dimethoxybenzamide	Others	Others
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

HY-103376

NBI-27914 hydrochloride	CRFR	Neurological Disease
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a K_i value of 1.7 nM .

HY-138813

N-Desethyl Sunitinib hydrochloride 5 Publications Verification SU-12662 hydrochloride	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

HY-101100

Anpirtoline hydrochloride D-16949 hydrochloride	5-HT Receptor	Neurological Disease
Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT_1B receptor agonist, with K_is of 28 nM (5-HT_1B), 150 nM (5-HT_1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects .

HY-116392B

DL-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice .

Cat. No.	Product Name	Type

HY-D1760

SBFI Sodium-binding benzofuran isophthalate	Fluorescent Dyes/Probes
SBFI is a membrane-permeant, fluorescent Na ⁺ indicator dye. SBFI is excited at 340 nm and the fluorophore emission is collected at 450 nm . SBFI selective for Na ⁺ over K ⁺ with K_d values of 20 and 120 mM for these ions, respectively. .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7503

Psoralenoside	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Source classification Metabolic Disease Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields	Histamine Receptor Calcium Channel Calmodulin
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-N4161

Euparin	Monophenols Source classification Phenols Plants Compositae Guilandina minax (Hance) G. P. Lewis	Reactive Oxygen Species
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-101238

Agmatine sulfate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Imidazoline Receptor NO Synthase Endogenous Metabolite
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

HY-N7504

Isopsoralenoside	Infection Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Psoralea corylifolia L. Plants Disease Research Fields	Bacterial
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-N1352

Rhuscholide A	Structural Classification Natural Products Monophenols Rhus chinensis Mill. Source classification Phenols Plants Anacardiaceae	HIV
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM .

HY-N8750

5-Acetyl-2-(1-hydroxy-1-methylethyl)benzofuran	Smallanthus sonchifolius (Poepp.) H.Rob. Structural Classification Natural Products Source classification Plants Compositae	Others
5-Acetyl-2-(1-hydroxy-1-methylethyl)benzofuran serves as a phytoalexin.

HY-N7724

Cedrusin (+)-Cedrusin	Styrax suberifolius Hook. et Arn. Source classification Styracaceae Plants	Others
Cedrusin is a benzofuran derivative that can be isolated from Styrax suberifolius .

HY-N12991

Picraquassioside B	Structural Classification Simaroubaceae Source classification Plants Saccharides Picrasma quassioides(D．Don)Benn． Monosaccharides	Others
Picraquassioside B is a benzofuran glucosides and can isolated from Cnidium monnieri fruits .

HY-N9224

5-Acetyl-6-hydroxy-2-(1-hydroxy-1-methylethyl)benzofuran	Structural Classification Monophenols Source classification Artemisia dracunculus L. Phenols Plants Compositae	Others
5-Acetyl-6-hydroxy-2-(1-hydroxy-1-methylethyl)benzofuran is a Phenols product that can be isolated from the herbs of Artemisia dracunculus. .

HY-N3805

Encecalin	Structural Classification Iridoids Terpenoids Source classification Helianthella quinquenervis (Hook.) A.Gray Plants Compositae	Others
Encecalin is a natural benzofuran compound .

HY-N1777

3,4-Dimethoxybenzamide	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Others
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

HY-N2827

Aglain C (-)-Aglain C	Structural Classification Natural Products Source classification Aglaia argentea Blume Plants Meliaceae	Others
Aglain C is isolated from A. ponapensis. Aglain C enhances the NF-kB inhibitory activity .

HY-101392R

Harmane (Standard)	Structural Classification Alkaloids other families Source classification Plants	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for *I1-Imidazoline* receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B**, respectively). Harmane exhibits comutagenic effect .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is an inhibitor that binds to benzodiazepine receptors (with an IC₅₀ value of 7 μM), has an IC₅₀ of 24 μM for muscarinic acetylcholine receptors (QNB), an IC₅₀ of 2.8 μM for opioid receptors, and IC₅₀ values of 163 and 101 μM for spironolactone and serotonin, respectively. Harmane is a selective monoamine oxidase inhibitor (with IC₅₀ values of 0.5 μM for MAO A and 5 μM for MAO B). Harman inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing levodopa (L-DOPA)-induced toxicity in PC12 cells. Harmane lowers blood pressure in rats through the *I1 imidazoline* receptor** (I1 receptor) and has antidepressant, anxiolytic, anticonvulsant, and analgesic effects. Harmane enhances the mutagenicity induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name	Chemical Structure

HY-B0556AS

Tetrahydrozoline-d4 hydrochloride
Tetrahydrozoline-d₄ (hydrochloride) is the deuterium labeled Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

HY-B0374S1

Moxonidine-d7
Moxonidine-d₇ is deuterated labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-B0374S

Moxonidine-d4
Moxonidine-d₄ (BDF5895-d4) is the deuterium labeled Moxonidine. Moxonidine(BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent[1][2].

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-B0374AS

Moxonidine-13C,d3 hydrochloride
Moxonidine- ¹³C,d₃ hydrochloride is ¹³C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

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