2. Immunology/Inflammation
  3. COX
  4. S-Diclofenac

S-Diclofenac  (Synonyms: ACS 15; ATB-337)

Cat. No.: HY-15035 Purity: 99.20%
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S-Diclofenac is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis.

For research use only. We do not sell to patients.

S-Diclofenac Chemical Structure

S-Diclofenac Chemical Structure

CAS No. : 912758-00-0

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Based on 1 publication(s) in Google Scholar

S-Diclofenac Related Antibodies

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Description

S-Diclofenac is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis[1].

Molecular Weight

504.47

Formula

C23H15Cl2NO2S3
CAS No.
Appearance

Solid

Color

Reddish brown to red

SMILES

O=C(CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1)OC3=CC=C(C(SS4)=CC4=S)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9823 mL 9.9114 mL 19.8228 mL
5 mM 0.3965 mL 1.9823 mL 3.9646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9823 mL 9.9114 mL 19.8228 mL 49.5570 mL
5 mM 0.3965 mL 1.9823 mL 3.9646 mL 9.9114 mL
10 mM 0.1982 mL 0.9911 mL 1.9823 mL 4.9557 mL
15 mM 0.1322 mL 0.6608 mL 1.3215 mL 3.3038 mL
20 mM 0.0991 mL 0.4956 mL 0.9911 mL 2.4778 mL
25 mM 0.0793 mL 0.3965 mL 0.7929 mL 1.9823 mL
30 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6519 mL
40 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2389 mL
50 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.9911 mL
60 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8259 mL
80 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6195 mL
100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4956 mL
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S-Diclofenac Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Diclofenac912758-00-0ACS 15 ATB-337ACS15ACS-15ATB337ATB 337ATB-337COXCyclooxygenaseInhibitorinhibitorinhibit

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