2. Membrane Transporter/Ion Channel Anti-infection Metabolic Enzyme/Protease
  3. Proton Pump Bacterial Phospholipase
  4. (S)-Lansoprazole

(S)-Lansoprazole  (Synonyms: Levolansoprazole)

Cat. No.: HY-13662C Purity: 99.17%
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(S)-Lansoprazole (Levolansoprazole) is an isoform of Lansoprazole (HY-13662), which is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).

For research use only. We do not sell to patients.

(S)-Lansoprazole Chemical Structure

(S)-Lansoprazole Chemical Structure

CAS No. : 138530-95-7

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Based on 1 publication(s) in Google Scholar

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(S)-Lansoprazole Related Antibodies

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Description

(S)-Lansoprazole (Levolansoprazole) is an isoform of Lansoprazole (HY-13662), which is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].

In Vitro

Lansoprazole from 0.3 to 3 μM inhibits gastric acid formation in a concentration-dependent manner (IC50 of 0.76 μM)[4].
? Lansoprazole (30-300 μM) both induced concentration-dependent, reversible and reproducible relaxations of arteries[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Lansoprazole Related Antibodies
In Vivo

Lansoprazole (20-40 mg/kg) treatment significantly attenuated STZ and HFD -induced memory deficits, biochemical and histopathological alterations[3].
Lansoprazole (20 mg/kg and 40 mg/kg, p.o.) significantly reduces the STZ and HFD- induced increase in AChE activity[3].
Lansoprazole (20 mg/kg and 40 mg/kg, p.o.) significantly reduces the STZ and HFD- induced rise in brain MPO level[3].
Further HFD mice treated with lansoprazole (20 mg/kg and 40 mg/kg, p.o.) shows a marked decrease in the body weight in comparison to the control animals[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

369.36

Formula

C16H14F3N3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=[S@@](CC1=NC=CC(OCC(F)(F)F)=C1C)C2=NC3=CC=CC=C3N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (338.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7074 mL 13.5369 mL 27.0739 mL
5 mM 0.5415 mL 2.7074 mL 5.4148 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7074 mL 13.5369 mL 27.0739 mL 67.6846 mL
5 mM 0.5415 mL 2.7074 mL 5.4148 mL 13.5369 mL
10 mM 0.2707 mL 1.3537 mL 2.7074 mL 6.7685 mL
15 mM 0.1805 mL 0.9025 mL 1.8049 mL 4.5123 mL
20 mM 0.1354 mL 0.6768 mL 1.3537 mL 3.3842 mL
25 mM 0.1083 mL 0.5415 mL 1.0830 mL 2.7074 mL
30 mM 0.0902 mL 0.4512 mL 0.9025 mL 2.2562 mL
40 mM 0.0677 mL 0.3384 mL 0.6768 mL 1.6921 mL
50 mM 0.0541 mL 0.2707 mL 0.5415 mL 1.3537 mL
60 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1281 mL
80 mM 0.0338 mL 0.1692 mL 0.3384 mL 0.8461 mL
100 mM 0.0271 mL 0.1354 mL 0.2707 mL 0.6768 mL
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(S)-Lansoprazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Lansoprazole138530-95-7LevolansoprazoleProton PumpBacterialPhospholipaseInhibitorinhibitorinhibit

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