2. Apoptosis
  3. Apoptosis
  4. (S)-Oxiracetam

(S)-Oxiracetam  (Synonyms: (S)-(-)-Oxiracetam; (S)-ISF2522)

Cat. No.: HY-126049 Purity: 98.78%
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(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke.

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(S)-Oxiracetam Chemical Structure

(S)-Oxiracetam Chemical Structure

CAS No. : 88929-35-5

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(S)-Oxiracetam Related Antibodies

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Description

(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].

In Vitro

(S)-Oxiracetam (1, 10, 100 μM; 24 h) protects fetal rat primary cortical neurons against OGD/R injury and activates PI3K/Akt/GSK3β signal pathway was α7 nAChR dependent[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Oxiracetam Related Antibodies

Cell Viability Assay[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Increased the survival of cortical neurons (58.82%, 64.82% and 79.15%, respectively) compared with the OGD/R group.

Cell Cytotoxicity Assay[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Decreased the LDH activity to 567.59 U/L, 484.89 U/L and 428.15 U/L at 1 μM, 10 μM and 100 μM, respectively, compared with the OGD/R group (725.22 U/L).

Apoptosis Analysis[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Reduced the apoptotic rate in cortical neurons dependent on α7 nAChR (34.48%, 16.15% and 10.05%, respectively) compared with the OGD/R group.

Western Blot Analysis[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Increased the expression of α7 nAChR (46.95%, 58.67% and 72.97%, respectively for the 1 μM, 10 μM and 100 μM) and the phosphorylation of PI3K, Akt and GSK3β dependent on α7 nAChR compared with the OGD/R group.
In Vivo

(S)-Oxiracetam (0.12, 0.24, 0.48 g/kg; i.v., once daily for 7 days) reduces the infarct size and lessens behavior dysfunction significantly, inhibits neuronal apoptosis, and activates PI3K/Akt/GSK3β signal pathway in Male Sprague-Dawley rats-induced MACO/R models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: scopolamine-induced amnesia models in Swiss albino mice[1].
Dosage: 0.12, 0.24, 0.48 g/kg, once daily for 7 days
Administration: Intravenous injection (i.v.)
Result: Decreased the infarct size of rats to 26.04 ± 1.07%, 21.66 ± 2.27%, 12.26 ± 5.59% compared with the sham group at 0.12 g/kg, 0.24 g/kg, 0.48 g/kg, respectively.
Increased neurological scores compared with the MCAO/R group.
Protected neurons from apoptosis compared to sham group.
Increased the α7 nAChR and the phosphorylation of PI3K, Akt and GSK3β expression compared with MCAO/R group.
Increased of GSH-PX concentration (189.54 units, 193.07 units, and 203.98 untis, respectively).
Molecular Weight

158.16

Formula

C6H10N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CN1C(C[C@@H](C1)O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1580.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3227 mL 31.6136 mL 63.2271 mL
5 mM 1.2645 mL 6.3227 mL 12.6454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.3227 mL 31.6136 mL 63.2271 mL 158.0678 mL
5 mM 1.2645 mL 6.3227 mL 12.6454 mL 31.6136 mL
10 mM 0.6323 mL 3.1614 mL 6.3227 mL 15.8068 mL
15 mM 0.4215 mL 2.1076 mL 4.2151 mL 10.5379 mL
20 mM 0.3161 mL 1.5807 mL 3.1614 mL 7.9034 mL
25 mM 0.2529 mL 1.2645 mL 2.5291 mL 6.3227 mL
30 mM 0.2108 mL 1.0538 mL 2.1076 mL 5.2689 mL
40 mM 0.1581 mL 0.7903 mL 1.5807 mL 3.9517 mL
50 mM 0.1265 mL 0.6323 mL 1.2645 mL 3.1614 mL
60 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6345 mL
80 mM 0.0790 mL 0.3952 mL 0.7903 mL 1.9758 mL
100 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.5807 mL
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(S)-Oxiracetam Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Oxiracetam88929-35-5(S)-(-)-Oxiracetam (S)-ISF2522Apoptosiscortical neuronsmiddle cerebral artery occlusion/reperfusion (MCAO/R) model in ratsbrain injury from ischemic strokeInhibitorinhibitorinhibit

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