2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. GABA Receptor NO Synthase
  4. Oxiracetam

Oxiracetam (ISF2522) is an orally active and a BBB-penatrable cyclic derivative of γ-aminobutyric acid (GABA). Oxiracetam reaches the hippocampus and cerebral cortex in high concentrations. Oxiracetam can promote cognitive function and regulate inflammatory response, with powerful neuroprotective effects. Oxiracetam can be used in the study of central nervous system diseases .

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Oxiracetam Chemical Structure

Oxiracetam Chemical Structure

CAS No. : 62613-82-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Oxiracetam:

Oxiracetam Related Antibodies

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nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Oxiracetam (ISF2522) is an orally active and a BBB-penatrable cyclic derivative of γ-aminobutyric acid (GABA). Oxiracetam reaches the hippocampus and cerebral cortex in high concentrations. Oxiracetam can promote cognitive function and regulate inflammatory response, with powerful neuroprotective effects. Oxiracetam can be used in the study of central nervous system diseases[1][2][3] .

In Vitro

Oxiracetam (100 μM; 12-24 h) inhibits Aβ-induced cell activation, inflammatory molecules expression and NO production in BV2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxiracetam Related Antibodies

Real Time qPCR[1]

Cell Line: Aβ treated BV2 microglial cells
Concentration: 100 μM
Incubation Time: 12 h
Result: Reduced the level of iNOS mRNA.
In Vivo

Oxiracetam (30 mg/kg; intraperitoneal injection; 4 weeks) improves cognitive impairment induced by chronic cerebral ischemia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Sprague-Dawley rats (220-240 g) with chronic cerebral hypoperfusion (CCH) model[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection (i.p.)； 4 weeks
Result: Prevented spatial learning and memory impairment induced by CCH.
Rescued the CCH-induced LTP decrease.
Prevented the white matter lesions of CA3 nerve fibres.
Maintained BDNF levels and CREB activity in rat brains.
Prevented CCH-induced deterioration of dendritic spines and synapses.
Clinical Trial
Molecular Weight

158.16

Formula

C6H10N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)CN1C(CC(O)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (632.27 mM)

DMSO : 25 mg/mL (158.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3227 mL 31.6136 mL 63.2271 mL
5 mM 1.2645 mL 6.3227 mL 12.6454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.3227 mL 31.6136 mL 63.2271 mL 158.0678 mL
5 mM 1.2645 mL 6.3227 mL 12.6454 mL 31.6136 mL
10 mM 0.6323 mL 3.1614 mL 6.3227 mL 15.8068 mL
15 mM 0.4215 mL 2.1076 mL 4.2151 mL 10.5379 mL
20 mM 0.3161 mL 1.5807 mL 3.1614 mL 7.9034 mL
25 mM 0.2529 mL 1.2645 mL 2.5291 mL 6.3227 mL
30 mM 0.2108 mL 1.0538 mL 2.1076 mL 5.2689 mL
40 mM 0.1581 mL 0.7903 mL 1.5807 mL 3.9517 mL
50 mM 0.1265 mL 0.6323 mL 1.2645 mL 3.1614 mL
60 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6345 mL
80 mM 0.0790 mL 0.3952 mL 0.7903 mL 1.9758 mL
100 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.5807 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxiracetam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxiracetam62613-82-5ISF2522ISF 2522ISF-2522GABA ReceptorNO SynthaseGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorNitric oxide synthasesNOSChronic cerebral ischemia modelBV2 cellsInhibitorinhibitorinhibit

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