(S,R,S)-AHPC-amido-C7-acid

Cat. No.: HY-148671 Purity: 98.28%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-amido-C7-acid Chemical Structure

CAS No. : 2172819-76-8

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs^[1].

Molecular Weight

600.77

Formula

C₃₁H₄₄N₄O₆S

CAS No.

2172819-76-8

Appearance

Solid

Color

White to off-white

SMILES

OC(CCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (166.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6645 mL	8.3227 mL	16.6453 mL
5 mM	0.3329 mL	1.6645 mL	3.3291 mL
10 mM	0.1665 mL	0.8323 mL	1.6645 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.28%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (252 KB) HNMR (360 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Sun N, et al. Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. J Med Chem. 2023 Jan 12;66(1):596-610. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6645 mL	8.3227 mL	16.6453 mL	41.6133 mL
	5 mM	0.3329 mL	1.6645 mL	3.3291 mL	8.3227 mL
	10 mM	0.1665 mL	0.8323 mL	1.6645 mL	4.1613 mL
	15 mM	0.1110 mL	0.5548 mL	1.1097 mL	2.7742 mL
	20 mM	0.0832 mL	0.4161 mL	0.8323 mL	2.0807 mL
	25 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6645 mL
	30 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3871 mL
	40 mM	0.0416 mL	0.2081 mL	0.4161 mL	1.0403 mL
	50 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8323 mL
	60 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6936 mL
	80 mM	0.0208 mL	0.1040 mL	0.2081 mL	0.5202 mL
	100 mM	0.0166 mL	0.0832 mL	0.1665 mL	0.4161 mL