(S,R,S)-AHPC-C3-NH2 TFA (Synonyms: VH032-C3-NH2 TFA)

Cat. No.: HY-130711A: FAQs
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(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C3-NH2 TFA Chemical Structure

CAS No. : 2688842-02-4

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Other Forms of (S,R,S)-AHPC-C3-NH2 TFA:

(S,R,S)-AHPC-C3-NH2 Get quote
(S,R,S)-AHPC-C3-NH2 hydrochloride Get quote
(S,R,S)-AHPC-C3-NH2 dihydrochloride Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
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Description

IC₅₀ & Target^[1]

VHL

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

629.69

Formula

C₂₈H₃₈F₃N₅O₆S

CAS No.

2688842-02-4

SMILES

OC(C(F)(F)F)=O.NCCCC(N[C@H](C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. [Content Brief]

(S,R,S)-AHPC-C3-NH2 TFA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C3-NH22688842-02-4VH032-C3-NH2E3 Ligase Ligand-Linker ConjugatesEED-TargetedVH032VHLPROTAClinkerInhibitorinhibitorinhibit

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