2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-C3-NH2

(S,R,S)-AHPC-C3-NH2  (Synonyms: VH032-C3-NH2)

Cat. No.: HY-130711
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(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form ((S,R,S)-AHPC-C3-NH2 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C3-NH2 Chemical Structure

(S,R,S)-AHPC-C3-NH2 Chemical Structure

CAS No. : 2361119-88-0

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Other Forms of (S,R,S)-AHPC-C3-NH2:

(S,R,S)-AHPC-C3-NH2 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-C3-NH2 Related Antibodies
Molecular Weight

515.67

Formula

C26H37N5O4S
CAS No.
SMILES

NCCCC(N[C@H](C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S,R,S)-AHPC-C3-NH2 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C3-NH22361119-88-0VH032-C3-NH2E3 Ligase Ligand-Linker ConjugatesEED-TargetedVH032VHLPROTAClinkerInhibitorinhibitorinhibit

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