2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-C3-NH2 hydrochloride

(S,R,S)-AHPC-C3-NH2 hydrochloride  (Synonyms: VH032-C3-NH2 hydrochloride)

Cat. No.: HY-130711B Purity: 96.38%
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(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C3-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-C3-NH2 hydrochloride Chemical Structure

CAS No. : 2940858-65-9

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50 mg USD 340 In-stock
100 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-C3-NH2 hydrochloride:

(S,R,S)-AHPC-C3-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-C3-NH2 hydrochloride Related Antibodies
Molecular Weight

552.13

Formula

C26H38ClN5O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (181.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8112 mL 9.0558 mL 18.1117 mL
5 mM 0.3622 mL 1.8112 mL 3.6223 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8112 mL 9.0558 mL 18.1117 mL 45.2792 mL
5 mM 0.3622 mL 1.8112 mL 3.6223 mL 9.0558 mL
10 mM 0.1811 mL 0.9056 mL 1.8112 mL 4.5279 mL
15 mM 0.1207 mL 0.6037 mL 1.2074 mL 3.0186 mL
20 mM 0.0906 mL 0.4528 mL 0.9056 mL 2.2640 mL
25 mM 0.0724 mL 0.3622 mL 0.7245 mL 1.8112 mL
30 mM 0.0604 mL 0.3019 mL 0.6037 mL 1.5093 mL
40 mM 0.0453 mL 0.2264 mL 0.4528 mL 1.1320 mL
50 mM 0.0362 mL 0.1811 mL 0.3622 mL 0.9056 mL
60 mM 0.0302 mL 0.1509 mL 0.3019 mL 0.7547 mL
80 mM 0.0226 mL 0.1132 mL 0.2264 mL 0.5660 mL
100 mM 0.0181 mL 0.0906 mL 0.1811 mL 0.4528 mL
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(S,R,S)-AHPC-C3-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C3-NH22940858-65-9VH032-C3-NH2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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