2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Sabcomeline hydrochloride

Sabcomeline hydrochloride  (Synonyms: SB-202026 hydrochloride; Memric hydrochloride)

Cat. No.: HY-106432A Purity: 99.86%
SDS COA Handling Instructions

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Sabcomeline (SB-202026) hydrochloride is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline hydrochloride can be used for Alzheimer's disease research.

For research use only. We do not sell to patients.

Sabcomeline hydrochloride Chemical Structure

Sabcomeline hydrochloride Chemical Structure

CAS No. : 159912-58-0

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5 mg USD 500 In-stock
10 mg USD 800 In-stock
25 mg USD 1600 In-stock
50 mg USD 2600 In-stock
100 mg USD 4200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sabcomeline hydrochloride:

Sabcomeline hydrochloride Related Antibodies

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  • Biological Activity

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Description

Sabcomeline (SB-202026) hydrochloride is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline hydrochloride can be used for Alzheimer's disease research[1][2].

IC50 & Target

Muscarinic M1 receptor[1][2]
Molecular Weight

229.71

Formula

C10H16ClN3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CO/N=C([C@@H]1C2CCN(CC2)C1)\C#N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (544.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3533 mL 21.7666 mL 43.5331 mL
5 mM 0.8707 mL 4.3533 mL 8.7066 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

SDS (252 KB)

COA (253 KB) HNMR (260 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.3533 mL 21.7666 mL 43.5331 mL 108.8329 mL
5 mM 0.8707 mL 4.3533 mL 8.7066 mL 21.7666 mL
10 mM 0.4353 mL 2.1767 mL 4.3533 mL 10.8833 mL
15 mM 0.2902 mL 1.4511 mL 2.9022 mL 7.2555 mL
20 mM 0.2177 mL 1.0883 mL 2.1767 mL 5.4416 mL
25 mM 0.1741 mL 0.8707 mL 1.7413 mL 4.3533 mL
30 mM 0.1451 mL 0.7256 mL 1.4511 mL 3.6278 mL
40 mM 0.1088 mL 0.5442 mL 1.0883 mL 2.7208 mL
50 mM 0.0871 mL 0.4353 mL 0.8707 mL 2.1767 mL
60 mM 0.0726 mL 0.3628 mL 0.7256 mL 1.8139 mL
80 mM 0.0544 mL 0.2721 mL 0.5442 mL 1.3604 mL
100 mM 0.0435 mL 0.2177 mL 0.4353 mL 1.0883 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sabcomeline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sabcomeline159912-58-0SB-202026MemricSB202026SB 202026mAChRMuscarinic acetylcholine receptorAlzheimer's diseaseInhibitorinhibitorinhibit

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